HOME >> BIOLOGY >> NEWS
Researchers map out networks that determine cell fate

A two-step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.

This finding sheds light on a puzzling behavior. For some differentiating stem cells, the first step leads not to a final decision but to a new choice. In response to the initial chemical signal, these cells take on the genetic signatures of two different cell types. It often requires a second signal for them to commit to a single cellular identity.

In the Aug. 25 2006 issue of Cell, the researchers, working with hematopoietic stem cells, which give rise to the many types of blood cells, show how "pioneer transcription factors" trigger the first step, pushing these stem cells towards this mixed lineage, midway between two related cell types -- in this case between a macrophage and a neutrophil.

Then one of two rival "secondary factors" activates the genes that lead to one cell type and shuts down the genes that lead to the alternative.

Understanding the circuitry that controls these decisions is central to learning how different kinds of stem cells develop. It provides insights into how to transform stem cells into therapeutically useful cells and suggests possible new treatments for leukemias, in which a persistent mixed lineage seems to drive cancerous proliferation.

Although the researchers worked only with blood-forming stem cells, they suspect that the same basic regulatory principles govern cell type determination in other tissues such as skin, brain and intestine.

"We see elements of this framework of primary and secondary cell-fate determinants throughout the hematopoietic system," said study author Harinder Singh, the Louis Block Professor of Molecular Genetics & Cell Biology and a Howard Hughes Medical Institute Investigator at the University of Chicago, "and we suspect such networks also regulate cell fate in other systems."

This f
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
30-Aug-2006


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... Md. (PRWEB) , ... October 11, 2018 , ... ... economy is the vision behind the National Institute for Innovation in Manufacturing Biopharmaceuticals ... array of projects designed to advance biopharmaceutical manufacturing and workforce development in the ...
(Date:10/5/2018)... ... October 04, 2018 , ... ... communications and collaboration solutions, was present at Microsoft Ignite 2018, in Orlando, Florida, ... solutions. , Microsoft issued a statement about the new direction of Skype for ...
(Date:10/5/2018)... PRINCETON, N.J. (PRWEB) , ... October 04, 2018 , ... ... will be exhibiting at the CDISC U.S. Interchange in Bethesda, MD on October 8-12, ... (BBSW), in Foster City, CA on November 5-6, 2018. , CDISC Interchanges are ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... ... September 28, 2018 , ... GlycoMark®, Inc. has ... of the GlycoMark test, the only FDA-cleared blood test specific to detecting recent ... promote and offer the GlycoMark test to its network of physicians through its ...
(Date:9/27/2018)... ... September 26, 2018 , ... NDA ... Cimler, a senior quality, regulatory, and in vitro diagnostic device expert with more ... industry has joined the firm as an Expert Consultant. Her experience includes leadership ...
(Date:9/27/2018)... ... September 26, 2018 , ... Medable was named DPharm ... build the first human digitome, a digital representation of human health and disease, ... integration of all data sources. Dr. Michelle Longmire, Co-Founder and CEO of Medable, ...
(Date:9/27/2018)... ... September 27, 2018 , ... This past weekend ... SureAdhere Mobile Technology, Inc. announced they will formally merge companies and integrate their ... tuberculosis (TB) and other diseases. These two social enterprise corporations, both of which ...
Breaking Biology Technology:
Cached News: