HOME >> BIOLOGY >> NEWS
Researchers pit novel version of common virus against cancer

With nearly $1 million in government funding, University of Rochester scientists are testing a new innovation in biotherapy by altering a common childhood respiratory virus, the adenovirus, to destroy cancer cells.

Exploring the potential of biotherapy through oncolytic adenoviruses is a hot area in cancer research. The approach is analogous to the police employing a snitch to reach the bad guys: For years scientists have been engineering relatively benign viruses to selectively infiltrate and deliver genetic materials into more dangerous cells.

However, the current generation of mutant viruses under study has limitations. So far, they are proving to be effective only in tumor cells that express certain proteins. The Rochester group designed an entirely new version of the adenovirus that might have broader, more powerful potential. The first experiments will be on pancreatic cancer, one of the deadliest malignancies.

Our concept is very promising and we hope it will open the door to safer and more effective treatments, said Baek Kim, Ph.D., associate professor of Microbiology and Immunology at the University of Rochester Medical Center and study co-investigator. If this works, the most exciting part is that patients would be able to generate their own internal weapons to kill the malignant cells without having to endure a toxic element such as chemotherapy.

Kim and co-investigator Stephen Dewhurst, Ph.D., senior associate dean for basic research at the University of Rochester, began looking at a novel approach to cancer treatment after investigating HIV/AIDS. Even though HIV and cancer are unrelated illnesses, they discovered a common link in the deadly efficiency of HIV cells and cancer cells.

Cancer cells are known to have a high concentration of dNTP, a building block of DNA. In fact, cancer cells require high dNTP concentrations in order to replicate their chromosomes fast enough to continually divide and inv
'"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
20-Jun-2007


Page: 1 2

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: