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Researchers provide study of early heart development and underlying cause of congenital heart defects

Researchers at The Burnham Institute for Medical Research have provided detailed insights into the early formation of the heart. A team lead by Dr. Rolf Bodmer found that two proteins, called Robo and Slit, are required for normal development of the heart and that malfunction of either of these proteins severely impacts the heart's structure, resulting in congenital heart defects. These findings were published in the journal Current Biology released on December 20th.

Congenital heart defects involve the malformation in one or more structures of the heart or blood vessels while the fetus is developing in the uterus. According to the American Heart Association, congenital heart disease affects about 35,000 infants each year, and claims the lives of "nearly twice as many children" annually in the United States "as die from all forms of childhood cancer". Symptoms may arise at birth, during childhood, and sometimes not until adulthood.

Working with Drosophilia melanogaster, also known as the fruitfly, the researchers showed that the Slit and Robo proteins accumulate in a specific alignment during the formation of the heart tube, a linear tube representing the primitive heart before its cells assume their rhythmical contractile functions. Proper alignment of the heart tube cells is critical for heart assembly and proper shape, or morphology. The researchers found that mutation or misexpression of these proteins leads to misalignment of the heart tube and results in observed heart defects.

"Although there is much interest in the understanding of the basis of heart tube assembly, little is known about the underlying molecular and genetic mechanisms that orchestrate heart development," said Rolf Bodmer, Ph.D., Professor at the Burnham Institute for Medical Research and corresponding author in the study. "These findings provide understanding of early controls in heart development, and we are eager to conduct further studies to reveal how t
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Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-646-3146
Burnham Institute
20-Dec-2005


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