HOME >> BIOLOGY >> NEWS
Researchers reverse juvenile diabetes in animal model; Clinical trial FDA approved

Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center researchers Massimo Trucco, MD, and Nick Giannoukakis, PhD, observed marked amelioration of diabetes in a mouse model by a novel treatment strategy involving specific modification of the animal's own dendritic cells, thereby reversing diabetes in animal studies.

The U.S. Food and Drug Administration (FDA) approved the start of a clinical trial to evaluate the safety and feasibility of the treatment (Phase 1 trial). The trial is expected to begin sometime this spring and will include at least 15 patients over the age of 18, with type 1 diabetes.

Dr. Trucco, director of the Division of Immunogenetics at Children's, and his research team will collaborate with Theresa Whiteside, PhD, scientific director at the University of Pittsburgh Cancer Institute.

Dr. Trucco and his team found that by removing dendritic cells from the blood during a two- to four-hour procedure, some 20 million dendritic cells can be harvested.

Dendritic cells are cells found in the bloodstream and normally function as one of nature's most efficient immune function cells. The cells identify foreign substances such as cancer cells, process these foreign substances, and then jumpstart the immune response by bringing these foreign substances to the attention of T cells.

Once harvested, researchers then combine the dendritic cells with specific blockers of molecules, known as CD40, CD80 and CD86, all of which can be synthesized in a laboratory. This treatment strategy was found to inhibit the interaction and destructive effect of T cells on the insulin-producing beta cells of the pancreas, a process that is known to be a critical part of how diabetes occurs.

Subcutaneous injection of dendritic cells into the abdominal/pelvic area near the pancreas and lymph nodes, blocks the T cells as they travel to the pancreas to destroy beta cells.

"We did this in mice, giving them s
'"/>

Contact: Melanie Finnigan
Melanie.Finnigan@chp.edu
412-692-5502
Children's Hospital of Pittsburgh
27-Mar-2006


Page: 1 2 3 4

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... 21, 2020 , ... Gateway Genomics , a leading developer of direct-to-consumer ... year’s annual Inc. 5000 list of fastest-growing private companies in the United ... be the 17th fastest-growing private company in the state, and #1 in the Health ...
(Date:2/13/2020)... (PRWEB) , ... February 13, 2020 , ... ... announce an exclusive interview with Nobio CEO Yoram Ashery to discuss ... Nobio is a company that combats bacteria to keep people healthy with their ...
(Date:2/7/2020)... , ... February 07, 2020 , ... ... consulting firm for the natural health product, nutraceutical and dietary supplement industries, announces ... been a leader in regulatory expertise and research pertaining to probiotics. We are ...
Breaking Biology News(10 mins):
(Date:1/22/2020)... ... 21, 2020 , ... Microbial Discovery Group LLC (MDG) is ... and Institutional (I&I) Account Manager. Darrell will focus on servicing MDG’s partners with ... 30 years of sales experience working across multiple different market sectors such as; ...
(Date:1/10/2020)... ... January 09, 2020 , ... A new report from ... the vendor qualification process, a critical element of clinical trial set up and ... the vendor qualification process creates delays in initiation in 7% of clinical trials ...
(Date:1/8/2020)... (PRWEB) , ... January 08, 2020 , ... ... metal wire composites that can achieve specific properties for use in harsh environments ... Metal Wire combines up to three metals or alloys to achieve specific ...
(Date:1/7/2020)... ... 07, 2020 , ... Vuja De Sciences (“Vuja De”), a biotechnology startup dedicated ... appointments of Chand Khanna, DVM, PhD, DACVIM (Onc), and Dr. Lee Helman, MD, to ... are delighted to welcome Chand and Lee as new directors. They will be of ...
Breaking Biology Technology:
Cached News: