HOME >> BIOLOGY >> NEWS
Researchers uncover new genes that control longevity

In an effort to understand the molecular mechanisms that control aging, Howard Hughes Medical Institute researchers and their colleagues have now uncovered 10 new genes that regulate longevity in yeast. The studies also suggest a new model for how aging is slowed when caloric intake is restricted.

Molecular biologists Matt Kaeberlein, Brian Kennedy, Stanley Fields, and colleagues at the University of Washington, reported in the November 18, 2005, issue of the journal Science that by decreasing the function of nutrient-responsive pathways such as TOR and Sch9, the life span of yeast is extended. Fields is a Howard Hughes Medical Institute investigator at the University of Washington.

The results of the studies are important because they begin to provide an explanation for the "life extension" effect seen in laboratory animals when food is restricted. So the studies could offer new clues about the molecular mechanisms that living organisms employ when food is scarce, said Fields.

Although it seems counterintuitive, experiments showed long ago that severely restricting food intake leads to an increase in longevity by as much as 40 percent -- in some animals. Although the longevity phenomenon was well documented in laboratory animals, researchers remained unsure about how it happened.

Now, the experiments by Kaeberlein, Kennedy, Fields and their colleagues are uncovering some of the molecular pathways that are involved in controlling longevity in yeast, and thus probably in more complex organisms.

"Through a large-scale screening process we have identified a set of genes that slows aging in yeast." Kaeberlein explained. He and his colleagues are hoping to use that model to expand their understanding of longevity higher up the evolutionary ladder, even into humans. "We speculate that it is important in higher organisms," Fields added, since very similar genes are found in most other species, from worms to fruit flies, mi
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
17-Nov-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... Conn. and TORONTO (PRWEB) , ... May 08, ... ... growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified eClinical ... II and III clinical trials and observational studies. Axiom is a leading e-clinical ...
(Date:5/7/2019)... (PRWEB) , ... May 07, 2019 , ... ... world’s first on-site Legionella DNA test in the UK. , In May, Landsec ... qPCR Legionella results in 45 minutes, enabling operators to take corrective action within ...
(Date:5/2/2019)... PHILADELPHIA (PRWEB) , ... April 30, 2019 , ... ... & Nadel LLP is pleased to announce that Gunes Bender, Ph.D., a ... firm’s life sciences practice group. In his new role, Bender provides technical support ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – ...
(Date:5/2/2019)... ... , ... Boston Robotic Hair Restoration announces the most advanced ... of painful hair transplant procedures. Boston Robotic Hair Restoration offers the newest, state-of-the-art ... solution to offer a minimally invasive procedure. With the ARTAS® iX robotics, patients ...
(Date:4/25/2019)... FRANCISCO (PRWEB) , ... April 24, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced global availability ... center software providers and enterprises of all sizes to harness the power of ...
(Date:4/16/2019)... FREDERICK, Md. (PRWEB) , ... April 16, 2019 ... ... will honor Blue Sources and their project partner, the U.S. Army Center for ... Retransfer of Aquatic Biomonitor Through Combined In-Licensing/Out-Licensing.” , Blue Sources, a veteran-owned company ...
Breaking Biology Technology:
Cached News: