HOME >> BIOLOGY >> NEWS
Researchers uncover new genes that control longevity

In an effort to understand the molecular mechanisms that control aging, Howard Hughes Medical Institute researchers and their colleagues have now uncovered 10 new genes that regulate longevity in yeast. The studies also suggest a new model for how aging is slowed when caloric intake is restricted.

Molecular biologists Matt Kaeberlein, Brian Kennedy, Stanley Fields, and colleagues at the University of Washington, reported in the November 18, 2005, issue of the journal Science that by decreasing the function of nutrient-responsive pathways such as TOR and Sch9, the life span of yeast is extended. Fields is a Howard Hughes Medical Institute investigator at the University of Washington.

The results of the studies are important because they begin to provide an explanation for the "life extension" effect seen in laboratory animals when food is restricted. So the studies could offer new clues about the molecular mechanisms that living organisms employ when food is scarce, said Fields.

Although it seems counterintuitive, experiments showed long ago that severely restricting food intake leads to an increase in longevity by as much as 40 percent -- in some animals. Although the longevity phenomenon was well documented in laboratory animals, researchers remained unsure about how it happened.

Now, the experiments by Kaeberlein, Kennedy, Fields and their colleagues are uncovering some of the molecular pathways that are involved in controlling longevity in yeast, and thus probably in more complex organisms.

"Through a large-scale screening process we have identified a set of genes that slows aging in yeast." Kaeberlein explained. He and his colleagues are hoping to use that model to expand their understanding of longevity higher up the evolutionary ladder, even into humans. "We speculate that it is important in higher organisms," Fields added, since very similar genes are found in most other species, from worms to fruit flies, mi
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
17-Nov-2005


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/9/2018)... ... August 08, 2018 , ... Specialty Med ... helps physicians bring the latest regenerative therapies and treatment options to their patients, ... 2018 in White Plains, NY. , The 2-day clinical collaboration ...
(Date:8/7/2018)... ... 2018 , ... Nurse practitioners and physician ... healthcare careers in the past year, according to the second annual survey of ... with a wide variety of career- and employment-related resources including physician/candidate database, job ...
(Date:8/7/2018)... ... 07, 2018 , ... Nanomedical Diagnostics , leading manufacturer ... titled, “Synthetic Molecules for Disruption of the Myc Protein-Protein Interface ” in ... Agile R100, described as a “ field-effect transistor (Bio-FET) platform ,” to produce ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson Gumpertz ... (AEC) experts with building owners and managers for a full-day discussion on health ... symposium comes to Boston for the first time on Thursday, 13 September 2018, ...
(Date:8/1/2018)... ... August 01, 2018 , ... Roland ... of a proprietary biofield energy treated supplement that potentially improves the anti-inflammatory ... systemic and organ-specific inflammation, as well as, immune function response. The following ...
(Date:7/31/2018)... ... 31, 2018 , ... Mahoney Environmental , a leading ... new website. The new website has been designed with improved functionality and navigation, ... Innovative to build a website created for the customer. The newly redesigned site ...
(Date:7/25/2018)... ... July 25, 2018 , ... Eileen Meagher, ... of a biofield energy treated nutraceutical to improve skin health parameters including anti-wrinkling, ... skin health and reported the following results:,     More than ...
Breaking Biology Technology:
Cached News: