HOME >> BIOLOGY >> NEWS
Researchers writing story of the 'alcoholic lung'

FORT LAUDERDALE, FL (Nov. 3, 2006) _ Chronic alcohol abuse disrupts the proteins that keep fluids out of the lung, lowers a protective antioxidant, disrupts immune defenses and can lead to a condition known as 'alcoholic lung,' according to research to be presented at the conference, "Physiological Genomics and Proteomics of Lung Disease." The findings give insight into how excessive drinking can harm the molecular life of the lung and lead to serious illness, including pneumonia and acute respiratory distress syndrome (ARDS).

The study "Chronic alcohol ingestion renders the lung epithelium susceptible to acute injury by alteration in granulocyte-macrophage colony-stimulating factor signaling and alveolar epithelial permeability," was carried out by David Guidot, Pratibha Joshi, Jesse Roman, Lou Ann Brown and Michael Koval of Emory University in Atlanta. Guidot and Joshi are also associated with the Veterans Affairs Medical Center in Atlanta.

"We're trying to understand what's happening with the alcoholic lung at the molecular level," said Koval, who will present the findings at The American Physiological Society lung disease conference taking place Nov. 2-5 in Fort Lauderdale.

Beyond the liver

Although chronic alcohol abuse is closely associated with liver disease, the condition affects many of the body's organs. In recent years, researchers have turned their attention to the 'alcoholic lung.'

Alcoholics are more susceptible to pneumonia and more than twice as likely to develop ARDS compared to non-alcoholics, Koval said. The alcoholic lung has been found to have lower levels of glutathione, an antioxidant that helps protect the lung from oxidative stress.

The Emory research team has found that alcohol disrupts claudins, a family of proteins that helps maintain a tight air-fluid barrier. This barrier allows air into the lung, while keeping blood and other potentially smothering fluids out.

Whe
'"/>

Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
3-Nov-2006


Page: 1 2 3

Related biology news :

1. Researchers find pathway that controls cell size and division
2. Researchers watch antibiotics, bacteria meet at atomic level
3. Researchers discover gene responsible for Restless Legs Syndrome
4. Researchers witness natural selection at work in dramatic comeback of male butterflies
5. Researchers discover human embryonic stem cells are the ultimate perpetual fuel cell
6. Researchers use new approach to predict protein function
7. Researchers probe risks, benefits of folic acid fortification
8. Researchers identify genetic mutation that may alter tumor cell proliferation
9. Researchers discover method for identifying how cancer evades the immune system
10. Researchers use adult stem cells to create soft tissue
11. Researchers find gene that spurs development of the epididymis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified periodontist ... the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding the ... Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from years ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... CARLSBAD, Calif. (PRWEB) , ... ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed ... combines CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... N.J. (PRWEB) , ... September 10, 2019 , ... ... development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... Forum, to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, ...
(Date:9/8/2019)... ... 2019 , ... Spartan Bioscience, the leader in on-demand DNA ... has been named Chief Financial Officer. , Spartan has also named former ... Additionally, Spartan has hired Steve Edgett as Executive Vice President to lead international ...
(Date:8/29/2019)... (PRWEB) , ... August 29, 2019 , ... ... chronic disease affecting grapevines, a feat they hope will ultimately help protect the ... Researchers including several Rochester Institute of Technology faculty and alumni sequenced the microbiome ...
Breaking Biology Technology:
Cached News: