Rewind, please: Nature paper shows that cell division is reversible

Oklahoma CityGary J. Gorbsky, Ph.D., a scientist with the Oklahoma Medical Research Foundation, has found a way to reverse the process of cell division.

The discovery could have important implications for the treatment of cancer, birth defects and numerous other diseases and disorders. Gorbsky's findings appear in the April 13 issue of the journal Nature.

"No one has gotten the cell cycle to go backwards before now," said Gorbsky, who holds the W.H. and Betty Phelps Chair in Developmental Biology at OMRF. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible."

Cell division occurs millions of times each day in the human body and is essential to life itself. In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible.

"Our studies indicate that the factors pointing cells toward division can be turned and even reversed," Gorbsky said. "If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion."

The findings may prove important to controlling the development and metastasis of certain cancers. It also holds promise for the prevention and treatment of birth defects and a wide variety of other conditions.

"Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEver, OMRF vice president of research. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division."

Gorbsky heads the Molecular, Cell and Developmental Biology Research Program at OMRF and holds both an M.A. and a Ph.D. in biology from Princeto

Contact: Adam Cohen
Oklahoma Medical Research Foundation

Page: 1 2

Related biology news :

1. Natures weapon against nerve agents
2. Natures secrets yield new adhesive material
3. Nature surrenders flowery secrets to international team
4. Nature Genetics and the International Society of Nephrology come to Danvers on World Kidney Day
5. UCSB study on sibling detection mechanism highlighted in Nature
6. USC study in Nature Genetics supports a stem cell origin of cancer
7. Biolex reports potential for more potent, efficacious antibodies in Nature Biotechnology
8. Natures process for nitrogen fixation caught in action
9. Origen publishes in Nature a robust and versatile method for creating transgenic chickens
10. FSU scientists biomolecular research published in Science, Nature
11. Nature meets technology at Georgia Techs conference on bio-inspired design

Post Your Comments:

(Date:11/12/2015)... , Nov. 11, 2015   Growing need ... analytical tools has been paving the way for ... determination of discrete analytes in clinical, agricultural, environmental, ... being predominantly used in medical applications, however, their ... sectors due to continuous emphasis on improving product ...
(Date:11/9/2015)... 09, 2015 ... the "Global Law Enforcement Biometrics Market ... --> http://www.researchandmarkets.com/research/52ggmn/global_law ) has announced the ... Biometrics Market 2015-2019" report to their ... ( http://www.researchandmarkets.com/research/52ggmn/global_law ) has announced the addition ...
(Date:10/29/2015)... MINNETONKA, Minn. , Oct. 29, 2015   ... that supports the entire spectrum of clinical research, is ... the Minnesota High Tech Association (MHTA) as one of ... in the "Software – Small and Growing" category. The ... and individuals who have shown superior technology innovation and ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... November 30, 2015 TapImmune, Inc. ... development of innovative peptide and gene-based immunotherapeutics and vaccines ... announced it will be presenting at the 8 th ... 2015 at 2.30 PM PT. Dr. John N. ... will be giving the presentation and will join TapImmune ...
(Date:11/30/2015)... BETHESDA, Md. , Nov. 30, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... to adding an additional independent director, and the Company ... investigation of allegations in a recent anonymous internet report ... on both initiatives. Linda Powers stated, ...
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... Technical Program that includes over 2,000 technical presentations offered in symposia, oral ... chemistry and applied spectroscopy, covers a wide range of applications such as, but ...
(Date:11/25/2015)... , Nov. 25, 2015  PharmAthene, Inc. (NYSE ... has adopted a stockholder rights plan (Rights Plan) in ... operating loss carryforwards (NOLs) under Section 382 of the ... --> PharmAthene,s use of its NOLs could ... change" as defined in Section 382 of the Code. ...
Breaking Biology Technology:
Cached News: