HOME >> BIOLOGY >> NEWS
Rockefeller researchers show evidence of asymmetric cell division in mammalian skin

It took almost 10 years for Elaine Fuchs, Ph.D., a Howard Hughes Medical Institute investigator at Rockefeller University, to find a postdoctoral fellow who shared her curiosity for the direction of cell divisions in the skin. Then Terry Lechler, Ph.D., came along and the result is a new paper published online last week in Nature detailing how asymmetric cell divisions are essential for skin development. Their findings challenge long standing ideas of how skin forms and functions and is one of the first documentations of asymmetric cell division in mammals.

The epidermis of the skin forms multiple layers, the outermost of which is at the body surface. The bottom, or basal, layer is attached to an underlying matrix, called a basement membrane, which contains many growth stimulating molecules. As cells move from the basal layer toward the surface, they differentiate and produce protective proteins before they finally die and are sloughed off.

"The epidermis creates a Saran Wrap seal for our body surface, keeping fluids in and harmful bacteria out," says Fuchs, who is the Rebecca C. Lancefield Professor and head of the Laboratory of Mammalian Cell Biology at Rockefeller. "Through experiments in cell culture in the 1980s, everyone believed that the epidermis maintained its protective function by ejecting cells from the basal layer and forcing them upward. Our data show that asymmetric divisions occur perpendicular to the basal layer, resulting in one of the two daughter cells being naturally displaced out of the basal layer. This opens up new ways to approach the pathology of different skin diseases and provides an explanation for how stem cells might generate one new stem cell and one differentiating cell at the same time."

Lechler first documented how often he saw cells in the basal layer of skin in mice dividing perpendicularly to the basement membrane below the bottom layer of cells. He found that at least 75 percent of all the cell division
'"/>

Contact: Kristine A. Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
15-Aug-2005


Page: 1 2 3

Related biology news :

1. Mary Frances Lyon to receive Rockefellers Pearl Meister Greengard Prize
2. Rockefeller University receives $45 million from NIH for clinical and translational science
3. Rockefeller researchers discover a biological clock within a clock
4. Rockefeller Universitys Titia de Lange receives NIH Pioneer Award
5. Thomas Eisner to receive 2005 Rockefeller University Lewis Thomas Prize for Writing about Science
6. Rockefeller University vaccine researchers selected for a grant offer from Foundation for NIH
7. Stem cell research at Weill Cornell, The Rockefeller University, and Sloan-Kettering
8. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
9. Innovative tagging technique may help researchers better protect fish stocks
10. Penn researchers discover how key protein stops inflammation
11. ASU researchers partner with UOP to make biofuel for military jets a reality

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... VISTAAR released ADVISORY Playbooks to ... as re-assurance / 2nd opinion to their internal strategies they formed for developing or ... going into new markets, or planning to change their product elements and want to ...
(Date:9/17/2019)... ... September 17, 2019 , ... Last week, Blackrock Microsystems, LLC, ... the Medical University of Warsaw, met at the Presidential Palace of the Republic ... neuroprosthetic system as part of an initiative called "Startups in the Palace – ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified ... of the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding ... the Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... The EnozoPro® converts ordinary tap water ... germs and pathogens on hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. ... For more information, visit the product page at rovingblue.com , ”At Enozo, our mission ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... in vitro toxicology testing solutions, announced the appointment of Mark McLoughlin to the ... the Board. , Mark McLoughlin will lend his healthcare expertise and extensive background ...
(Date:8/7/2019)... ... , ... Locus Agricultural Solutions (Locus AG) reports record levels of carbon sequestered ... Rhizolizer ® , which is pulling up to 121% more carbon into the soil ... Results from the treatment of almonds, cherries, turf/sod, grapes and citrus across the U.S., ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a ... a distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the ... July/August special issue. , As the executive vice president of business development and ...
Breaking Biology Technology:
Cached News: