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SPECT imaging can evaluate stem cell therapy effectiveness in patients with coronary heart disease

after stem cell infusion," added the co-author of "Evaluation of Myocardial Segmental Perfusion and Function After Intracoronary Peripheral Stem Cell Infusion in Patients With Acute Myocardial Infarction Using Gated Myocardial SPECT" and "Assessment of Tissue Distribution of F-18 FDG Labeled Hematopoietic Stem Cell After Intracoronary Administration in Patients With Myocardial Infarction."

Myocardial SPECT is a well-established method for assessing myocardial blood flow in patients with ischemic heart disease. With SPECT, information can be obtained on global function, heart volume and regional blood flow and function. "Gated myocardial SPECT can compare function before and after a successful treatment," said Lee.

Korean researchers also labeled stem cells with F-18 FDG (fluorodeoxyglucose) and successfully assessed tissue distribution. "The use of PET to evaluate stem cell treatment of heart disease adds specificity and feedback to stem cell treatment," said Josef Machac, M.D., director of the clinical PET center and nuclear medicine at Mount Sinai School of Medicine, New York, N.Y., and a vice chair of SNM's Scientific Program Committee (Cardiovascular Track). "Rather than just infusing the stem cells, closing one's eyes and hoping for the best, the imaging of F-18 FDG-labeled stem cells provides valuable information about the location and number of cells successfully implanted. One can then link this with eventual improvement in function, investigated by the same group with gated myocardial SPECT," Machac explained.


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Contact: Maryann Verrillo
mverrillo@snm.org
703-708-9000
Society of Nuclear Medicine
20-Jun-2005


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