HOME >> BIOLOGY >> NEWS
Salk scientists hammer out a pathway that promotes muscle cell survival in mice

LA JOLLA, CA -- Scientists at the Salk Institute for Biological Studies have identified an enzyme that pumps up a cells ability to maintain healthy muscle and restores normal muscle function in genetically engineered mice with weak muscles. The study, published online in Nature Medicine, is the first to explore the part this enzyme plays in a cascade of events triggered by exercise-induced hormones and other signals.

In this particular pathway, a molecular switch turns on a set of muscle-specific genes in response to exercise by releasing a brake that normally keeps these genes off. Learning how this pathway affects cellular responses may provide clues for improving cellular health in diseases affecting muscle and other cell types.

"In addition to muscle, this regulatory circuit is present in brain and heart tissue, where it also seems to control cell survival," said Marc Montminy, M.D., Ph.D., professor in the Clayton Foundation Laboratories for Peptide Biology at the Salk Institute and senior author of the study. "Therefore, we believe that understanding the role of this enzyme in muscle cells may someday shed light on the underlying mechanisms of many diseases that affect cell survival, such as muscular dystrophy, neurodegenerative diseases, and congestive heart failure."

Montminys team, led by postdoctoral researcher Rebecca Berdeaux, Ph.D., first became interested in the enzyme when they observed that mice engineered to have a defect in a molecular switch, called cAMP responsive element binding protein (CREB), had hunched backs, muscle wasting, and other signs of unhealthy muscles. Although CREB had long been studied for its role in glucose regulation in metabolic tissues like the liver and pancreas, its function in muscle tissue was unknown. Then, the researchers noticed that mice lacking CREB activity in their muscle cells also had a genetic brake, called histone deacetylase (HDAC), stuck in place. Without loosening the bra
'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
29-Apr-2007


Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 19, 2020 , ... ... operations management solutions, today introduced BioMed to their award-winning computerized maintenance management ... connecting the people and systems around biomedical engineering to better allocate staff ...
(Date:5/21/2020)... Mass. (PRWEB) , ... May 21, 2020 , ... ... orthopedic care across the North Shore and Greater Boston area, is pleased to ... , As one of the busiest group practices in the area, Agility Orthopedics ...
(Date:5/14/2020)... Kan. (PRWEB) , ... May 13, 2020 , ... ... American launch of Bonlacta™, its latest enzyme for the lactose-free dairy market. This ... a wide range of lactose-free dairy products at competitive costs across North America. ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... Fla. (PRWEB) , ... May 05, 2020 , ... ... and solutions company, announced today the launch of its iGlucose® LTE ... new iGlucose solution utilizes LTE Cat-M1 technology, the industry’s newest and broadest cellular ...
(Date:4/22/2020)... (PRWEB) , ... April 20, 2020 , ... ... offices in Cambridge, MA, announced today that Omixon’s founder and chairman Dr. Attila ... of Omixon’s flagship product Holotype HLA since 2014 before stepping into the CEO ...
(Date:4/7/2020)... ... 2020 , ... Gateway Genomics , leading developer of direct-to-consumer genetic tests ... DNA Tests sold in March, just months after attaining the 150,000-test landmark in ... a mom could order her kit online, collect a DNA sample from her home, ...
(Date:4/1/2020)... GOES, Netherlands (PRWEB) , ... ... ... company, Molecular Biology Systems, B.V. (MBS) has developed a method using its ... SARS-CoV-2 to eight minutes. Combined with smaller reaction volumes, increased samples per ...
Breaking Biology Technology:
Cached News: