HOME >> BIOLOGY >> NEWS
Scientists, linking gene with serotonin and depression, offer insights to new treatments

ers analyzed tissue from a mouse model of depression as well as post-mortem tissue from depressed human patients, and found decreased levels of p11 protein in both cases. On the other hand, p11 levels increased in rats and mice that were treated with anti-depressant medications or electroconvulsive therapy.

To further test the connection, Svenningsson and his colleagues genetically engineered two strains of mice: one that produced more p11 than normal and another that produced no p11 at all. They found that mice that overexpress p11 were hyperactive and, in a test designed to identify depression in rodents, acted just like mice that were on anti-depressant medication. Mice that lacked p11, meanwhile, acted depressed and showed less responsivity to anti-depressant medications.

Taken together, the findings point to p11 as a new target for developing depression treatments.

"In addition to exploring ways to increase p11 in depressed patients, it may also be possible to develop peptide-based compounds that can mimic the action of p11 to achieve a new class of anti-depressant compounds," Svenningsson says.

In addition to Svenningsson and Greengard, the study's other authors are Ilan Rachleff and Marc Flajolet at Rockefeller; Karima Chergui and Xiaoqun Zhang at Karolinska; Malika El Yacoubi and Jean-Marie Vaugeois at the University of Rouen; and George G. Nomikos at Eli Lilly.


'"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
5-Jan-2006


Page: 1 2

Related biology news :

1. Research linking Ashkenazi Jews and breast cancer genes beset by problems
2. New study warns against linking ethnic identity to breast cancer genes
3. Stronger evidence found linking Epstein-Barr virus and risk of multiple sclerosis
4. Lung surfactant: Host defense/surface tension, and linking innate/adaptive immune systems
5. Researchers find pathways linking caloric restriction to aging process
6. NYU researchers discover mechanism linking color vision and cancer genes
7. Engineers improve plastics potential for use in implants by linking it to biological material
8. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes
9. Low levels of neurotransmitter serotonin may perpetuate child abuse across generations
10. Forsyth scientists find linkages between serotonin reuptake inhibitors and bone mass
11. Transporters for the brain chemical serotonin provide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2019)... , ... February 21, 2019 , ... Clean label food ... expected when creating natural foods and beverages. It is quite common to spot consumers ... Yet, meat products are not immune to this label scrutiny. , More than ...
(Date:2/19/2019)... ... February 20, 2019 , ... ... that will see Dimensions rolled out across the organization. Dimensions provides in-depth ... across their business, support strategic planning, and understand past and future funding ...
(Date:2/14/2019)... ... February 14, 2019 , ... This year’s conference in ... 80 scientific sessions and 2,100 presentations. Given SOT’s mission to bring together researchers ... OpenLiver™ 3D cell culture model initiative that it recently launched with Biopredic ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars, or click below to learn more about each webinar: , CLINICAL ...
(Date:1/30/2019)... ... January 29, 2019 , ... Could a computer detect a ... tricky math problem on an online tutoring program? Could it detect deep reflection ... science assistant professor Erin Solovey is working to develop a system ...
(Date:1/24/2019)... ... ... Controlled Contamination Services is pleased to announce three exciting new additions to ... team members will support its growing operation across the US and will be a ... This addition will enable CCS to widen its reach and provide enterprise wide solutions ...
(Date:1/20/2019)... ... January 16, 2019 , ... On January 15 of ... news article by Asymmetrex director James L. Sherley, M.D., Ph.D. The ... resources like the PGCB and CellTrials.org. Now in its 21st year of operation, ...
Breaking Biology Technology:
Cached News: