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Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

reasing scientific evidence that suggests that inflammation is a key component of onset and progression of metabolic disease. We have already identified potent lipoxygenase inhibitors that have shown activity in preclinical animal models of diabetes and are evaluating more potent and pharmacologically optimized leads in appropriate animal models."

About Lipoxygenases
Lipoxygenases are enzymes which play a key role in the synthesis of inflammatory mediators called leukotrienes, and trigger the progression of several diseases mediated by inflammation. Two key members of the lipoxygenase pathway, 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) have been indicated in a number of diseases states including asthma, arthritis, atherosclerosis, diabetes, osteoporosis, and cancer. Lipoxygenases are common in plants where they are involved in modulating a number of diverse physiological aspects including signaling, growth and development, pest resistance, and senescence, or response to wounding.

About CIP Modulators Galileo's proprietary drug discovery platform exploits the similarities between the genomes of plants and humans to rapidly identify drug-like compounds, which can then be modified and optimized into small molecule drug compounds. Several pathways regulating inflammation are found in both plants and animals. Examples of target classes within these conserved pathways that are amenable to Galileo's Conserved Inflammatory Pathway (CIP) platform include kinases, lipoxygenases, nuclear receptors, and phosphatases. Galileo has demonstrated that several of the compounds produced by the plants in response to stress to regulate specific pathways also modulate the corresponding human pathway. Galileo uses the stress-induced plant compound libraries as starting points and applies its medicinal chemistry optimization to develop small molecule drug candidates for the treatment of inflammatory and metabolic disease.


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Contact: Angela Bitting
a.bitting@comcast.net
925-202-6211
AB Corporate Communications
22-Jul-2005


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