HOME >> BIOLOGY >> NEWS
Scientists clone mice from adult skin stem cells

For cells that hold so much promise, stem cells' potential has so far gone largely untapped. But new research from Rockefeller University and Howard Hughes Medical Institute scientists now shows that adult stem cells taken from skin can be used to clone mice using a procedure called nuclear transfer. The findings are reported in the Feb. 12 online edition of the Proceedings of the National Academy of Sciences.

Embryonic stem cells have received the most press for their potential to generate healthy cells and tissues that could replace damaged or diseased organs. "Scientists are well-aware that tissue derived from someone else's embryonic stem cells would be recognized as foreign and rejected by the patient," says senior co-author Elaine Fuchs, the Rebecca Lancefield Professor at Rockefeller and a Howard Hughes Medical Institute investigator. "This is one of the reasons why scientists have focused so much attention toward using nuclear transfer, which would allow us to use adult stem cells from the same patient rather than those harvested from an unrelated embryo."

Fuchs and her colleagues tested the method in adult stem cells taken from the skin of mice.

Using purification methods developed in Fuchs' Laboratory of Mammalian Cell Biology and Development, postdocs Valentina Greco and Graldine Guasch isolated stem cells from the mice's hair follicles. They gave these stem cells to Jinsong Li, a postdoc in Rockefeller's Laboratory of Developmental Biology and Neurogenetics, headed by senior co-author Peter Mombaerts. To execute the nuclear transfer procedure, Li took unfertilized mouse oocytes and replaced the nucleus of each oocyte with a nucleus from these adult skin stem cells.

A main hurdle in nuclear transfer with adult cells has been its efficiency out of a hundred attempts, only a handful may succeed with reported success rates never reaching into double digits. "The efficiency of nuclear transfer is very low," says
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
12-Feb-2007


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists clone mice from adult skin stem cells

(Date:5/22/2013)... Bethesda, Md. (May 22, 2013)The omega 3 fatty acids ... against cardiovascular diseaseso much so that the American Heart ... fish a week, particularly fatty varieties rich in omega ... remains a mystery. In a new study, scientists led ... light on this phenomenon by providing evidence that fish ...
(Date:5/22/2013)... changes in cellular DNA can endanger the whole organism, ... Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how ... double helix. , The DNA in our cells controls ... our bodies. The instructions for this are encoded in ... DNA, the bases adenine (A), cytosine (C), guanine (G) ...
(Date:5/22/2013)... 2013 Early screening for prostate cancer could become ... for women, thanks to UC Irvine research published today ... . , After more than a decade of work, ... identify clinically usable markers for prostate cancer in urine, ... with greater accuracy and at dramatically lower cost. The ...
Breaking Biology News(10 mins):Fish oil may help the heart beat mental stress 2DNA damage: The dark side of respiration 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3
(Date:5/24/2013)... , May 24, 2013 InspireMD, ... in embolic protection stents, announced that Alan Milinazzo ... Craig Shore , the Company,s Chief Financial ... Conference on Thursday May 30, 2013 at The Pfister Hotel, ... The format of the conference includes a number ...
(Date:5/24/2013)... Toronto, Canada (PRWEB) May 24, 2013 ... selective barriers, and uptake or efflux transporters at the ... may be related to unbound fractions in the tissue ... understanding of these disposition challenges is required to guide ... and to identify any species-dependent variables that may impact ...
(Date:5/24/2013)... 2013 Quincy Bioscience, a leading ... of calcium-binding proteins to support healthy living, is ... study of apoaequorin in Food and ... the British Industrial Biological Research Association. , ... potential adverse effects, if any, of apoaequorin, in ...
(Date:5/23/2013)... 23, 2013 Venaxis, Inc. (Nasdaq:   APPY), ... obtaining FDA clearance and commercializing its rapid, protein biomarker-based ... of an underwritten public offering of 10,000,000 shares of ... shares of its common stock at an exercise price ... price of $1.25 per share and related warrant.  Venaxis ...
Breaking Biology Technology:InspireMD To Participate In Benchmark Investor Conference On May 30th 2InspireMD To Participate In Benchmark Investor Conference On May 30th 3InspireMD To Participate In Benchmark Investor Conference On May 30th 4DMPK for Targeted Tissue Delivery: Solutions for the Most Challenging Part of Outsourcing, New Life Science Webinar Hosted by Xtalks 2Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3
Cached News: