HOME >> BIOLOGY >> NEWS
Scientists decode RNA mystery, will help aim drug therapies

A team of University of Maryland scientists have made a discovery that will help better direct drug therapies to their molecular targets.

As reported in the June 13 issue of the online journal PLoS ONE, the researchers, led by Jonathan Dinman, assistant professor of cell biology and molecular genetics at the University of Maryland, have found the difference between two closely related components in the messenger RNA (mRNA) near-cognate and non-cognate codons terms that have long been used, but not understood.

Although these two terms have been used by scientists for over 40 years, the differences between them have never been properly defined. Here, we have made this determination at both the molecular and mechanistic levels, and developed a simple drug-based test to differentiate them. Its a real step in designing the pathway of rational drug design.

Defining the Codons

Messenger RNA tells the ribosome what kind of proteins to make and how much to crank out. The codons specify which amino acids should end up in the protein, says Dinman. If the wrong codon is selected, the wrong amino acid ends up in the protein, which can alter or destroy the function of that protein and cause human disease.

Codons are the three-part packets of information in DNA that specify amino acids. They are read by corresponding packets in aminoacyl tRNAs (aa-tRNA) called anticodons. Codons are among the many components that James Watson, Francis Crick, Franois Jacob, Jacques Monod, Marshall Nirenberg and others found in their discoveries of DNA and genetic code in the late 1950s and early 1960s.

Crick coined the terms near-cognate and non-cognate codons but he didnt really define the difference, says Dinman. In fact, no one really ever has defined them, until now. Its been fuzzy.

Cognate tRNAs properly decode genetic information in mRNAs, while near- and non-cognate tRNAs correspond to close but no cigar and fuggedab
'"/>

Contact: Ellen Ternes
eternes@umd.edu
301-405-4627
Public Library of Science
12-Jun-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... , ... June 04, 2020 , ... “Although we are ... and well-being of our attendees, staff, and the public. We remain committed to ... safe ways to collaborate virtually,” said Julie Sutcliffe, President of WMIS. ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... software developer and solutions provider, today reported that the implementation of browser-based, ... compliance by 100%, resulting in greater efficiency for global biotechnology company, bioMérieux. ...
(Date:5/28/2020)... ... ... CrucialTrak, a global designer and manufacturer of biometric access control systems, today ... and sell its complete line of biometric readers and access gates . CEG ... . , Brett Mason, CrucialTrak’s Director of Channel Sales for the Americas is ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... In ... commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to ... by Dr MA has been using the zebrafish model to investigate the causes ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... of 40% in 2020, despite many obstacles created as a result of COVID-19. ... revenue for its partnered medical practices and medical manufacturers by expanding access to ...
(Date:6/28/2020)... SAN JOSE, Calif. (PRWEB) , ... June 25, ... ... the globe, researchers are racing to develop a vaccine or drug treatment. In ... company Recursion has publicly released the world’s largest imaging dataset portraying ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis Corporation, ... announced today that Derek Fournier has been appointed CEO and President. Founder and ... effective immediately. , “DeCurtis Corporation has been on an incredible journey for ...
Breaking Biology Technology:
Cached News: