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Scientists develop new concept with potential to help predict how individuals may respond to drugs

cal industry. The 'pharmaco-metabonomic' approach is able to account for genetic as well as many environmental factors, and other important contributors to individual health such as the gut microfloral activity. These factors strongly influence how an individual absorbs and processes a drug and also influence their individual metabolism, making this new approach the first step towards the development of more personalised healthcare for large numbers of patients."

The discovery of this new technology for predicting responses to drugs, which is not limited to individual genetic differences, will hopefully be a key component in the pharmaceutical industry's aim to understand how patients might benefit from more individualised therapies. The new method is expected to be synergistic with existing pharmacogenomic approaches.

The new methodology is in early stage of development and will be studied in humans to evaluate its possible clinical application. The researchers hope this new technique might one day allow doctors to personalise drug treatments for some individuals, providing physicians with the ability to prescribe medicines that will be most effective for certain patient groups, and at a tailored dose-range for maximum efficacy and safety.


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Contact: Tony Stephenson
at.stephenson@imperial.ac.uk
44-207-594-6712
Imperial College London
19-Apr-2006


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