HOME >> BIOLOGY >> NEWS
Scientists discover a genetic switch that links animal growth and cancer

are proteins called tumor suppressors.

Working with a tiny roundworm known as Caenorhabditis elegans, an important animal model in biomedical science, the researchers discovered that a tumor suppressor known as PTEN also functions to keep the animal in a waiting state by blocking cell growth when food is absent.

If these animals hatch from their eggs without any source of nutrition, they are able to remain in a perpetually young state for a long time without growing. When they eventually find food they start growing and maturing into adults. The researchers discovered that this juvenile-to-adult switch is controlled by PTEN. When the gene for PTEN is defective, the animals attempt to grow and become mature even when they have no food.

"The attempt of these animals to grow when they should not is not only analogous to the inappropriate growth and proliferation of cells during the formation of tumors in cancer, it also involves the same players," said Rothman. The research team found that PTEN functions with two other proteins known as protein kinases that are also involved in cancer progression.

This discovery means that other proteins that keep the brakes on growth might be found by looking for additional genes that keep these animals in an immature state.

"Now that we have information about the switch that keeps animals developmentally arrested, we can readily identify other genes involved in this process," said Rothman. Such genes might similarly be involved in the formation of cancers and could provide new therapeutic targets for intervention in cancer.

The current findings took about four years to discover. The worms used in the research develop quickly, growing from an egg to an adult in three days, as compared to mice, for example, which take several months. The similarities between the number and identity of genes in humans and worms allow researchers to extrapolate from worms to humans in their genetic resea
'"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
17-Apr-2006


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market releases photos and ... Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. Verdi ... CEO of NXT-ID thanked his investors and employees "for their work ...
(Date:10/14/2014)... (Oct. 14, 2014)—It,s been millions of years since ... team led by Ohio University scientists is breathing life ... airflow through dinosaur snouts. The research has important implications ... breathe but to enhance the sense of smell and ... animals," said Ohio University doctoral student Jason Bourke, lead ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
(Date:10/25/2014)... 2014 DuPont Pioneer and Perdue ... than double the acreage contracted for Plenish® high ... soybean crush facility in Salisbury, Md. The high ... target several markets including foodservice and food manufacturers ... , For the 2015 growing season, Perdue Agribusiness ...
(Date:10/25/2014)... October 24, 2014 SonaCare Medical, ... ultrasound (HIFU) technology, announced that its Board of ... Chief Executive Officer, President and member of the ... Carol will take-on expanded responsibilities within the company, ... well as overseeing commercialization, manufacturing and finance. ...
(Date:10/25/2014)... DALLAS and NEW YORK ... Biopharmaceuticals, Inc. (OTCQB: ACCPD), formerly Access Pharmaceuticals, Inc. ... critical areas, announced it has implemented a 1-for-50 ... the opening of trading on Friday, October 24, ... split-adjusted basis under new CUSIP number 72754H109 and ...
(Date:10/25/2014)... , October 24, 2014 ... http://www.researchandmarkets.com/research/t5t5pd/the_global_market ) has announced the addition of ... Graphene And Other 2-D Nanomaterials "  report ... http://photos.prnewswire.com/prnh/20130307/600769) , ,CNTs and graphene are the ... to man, with a performance-per-weight greater than ...
Breaking Biology Technology:DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 2DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 3DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 4SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4
Cached News: