HOME >> BIOLOGY >> NEWS
Scientists discover that three molecules may be developed into new Alzheimer's drugs

(Santa Barbara, Calif.) A team of scientists has discovered three molecules from a search of 58,000 compounds that appear to inhibit a key perpetrator of Alzheimer's disease.

Each of the three molecules protects the protein called "tau," which becomes hopelessly tangled in the brains of patients with Alzheimer's. The finding is promising news for the development of drugs for the disease.

Ken Kosik, co-director of the Neuroscience Research Institute at the University of California, Santa Barbara, headed the effort to find these molecules. The results of the study are published in the July issue of the journal Chemistry and Biology, released on Friday, July 22.

As baby boomers grow older, the incidence of Alzheimer's, already increasing, will rise much more. "Our approaches to the disease are flagrantly inadequate," said Kosik.

"There are a couple of FDA-approved drugs that help a little, but don't modify the disease. They give a little bit of symptomatic relief, but don't change the inexorable progression of the disease."

He said that new insights made over the past decade help to understand the molecular and genetic basis of the disease and these can now be built upon for the development of treatments. "There is no doubt that we need new approaches," said Kosik. "The insights gained about the mechanisms of the molecular and genetic basis of the disease are beginning to add up and can be harnessed for treatments."

Alzheimer's involves a complicated, interwoven series of regulatory steps of genes and proteins "talking" to each other, he explained. "When the conversation goes awry the disease process begins. And it is not just one gene or one protein causing the damage."

The complexity of Alzheimer's means that several different medications will likely be needed to control it, said Kosik. The same is true for many other diseases from AIDS to cancer. "It is likely that we will need to strategically target diff
'"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
22-Jul-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/26/2019)... (PRWEB) , ... March 26, 2019 , ... ... proud to introduce the four recipients of the Society's 2019 Outstanding Achievement Award, ... four awards will be presented at the ASGCT 22nd Annual Meeting . ...
(Date:3/25/2019)... ... March 25, 2019 , ... Abcam, ... research organisation focused on advancing drug discovery, have announced a collaboration to develop ... clearing methods, which are essential to get a better view of complex structures ...
(Date:3/18/2019)... ... March 18, 2019 , ... Periodontal disease, where bacterial infection of ... 50% of the US population. Making this disease particularly challenging to treat is ... the cells are enmeshed in a sticky extracellular material that makes them more resistant ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny for ... approximately two months. After a series of diagnostics, an MRI was performed which ... Alison, researched the injury and found that VetStem Regenerative Cell Therapy may ...
(Date:4/8/2019)... , ... April 08, 2019 , ... US Capital ... a $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma ... drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to ...
(Date:4/4/2019)... BOSTON (PRWEB) , ... April 03, 2019 , ... ... leaders together through intimate off-the-record collaboration and dialogue, today announces its Boston CEO ... CEO offers insights into the industry’s challenges and opportunities with high-level panels and ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u ... of healthy meals and good nutrition. This month, Chef Jodi Abel appeared on ... , The first segment addressed the nutritional value of USDA’s MyPlate, a ...
Breaking Biology Technology:
Cached News: