HOME >> BIOLOGY >> NEWS
Scientists discover way to block growth of prostate cancer cells

Prague, Czech Republic: Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

They found that a drug that blocks this pathway significantly prolonged survival and inhibited tumour development in mice that were genetically engineered to spontaneously develop prostate cancer and die of the disease. The hope is that this drug could be used eventually to treat men at high risk of developing prostate cancer and to prevent recurrences in men already treated for primary tumours.

Dr Hirak Basu told a news briefing at the EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Wednesday 8 November): "Previous work has demonstrated that androgen treatment increased reactive oxygen species levels in androgen-dependent prostate cancer cells, but, until now, the pathway involved was unknown."

Dr Basu is an associate scientist and principal investigator in the Prostate Cancer Group at the Paul P. Carbone Comprehensive Cancer Center, Madison, WI, USA. He and his collaborators at the centre found that levels of a key enzyme, spermidine/spermine acetyl transferase (SSAT), which starts oxidation of polyamines, rose markedly when prostate cancer cells were treated with androgen. Polyamines are small molecules produced in large quantity by the prostate gland and are secreted in the seminal fluid. Oxidation of polyamines generates a large amount of the ROS, hydrogen peroxide. Peroxide causes oxidative stress, a condition in which cells produce an excess of oxygen-free radicals, which are known to play a key role in cell signalling and prostate cancer development.

"These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prostate cancer c
'"/>

Contact: Emma Mason
wordmason@mac.com
44-077-112-96986
European Organisation for Research and Treatment of Cancer
8-Nov-2006


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... The August edition of ... now available on the company’s global website. Crystallography Times—an electronic newsletter published by ... news and crystallographic research. , The latest issue of Crystallography Times introduces ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than twenty years. Together ... book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont Nutrition ... in Wuxi, China. The new plant operation will provide the local animal production ... , “This facility will improve the flexibility of our offerings to the ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... today announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption ... industry and around the globe, requiring fast track capacity to provide patients with ...
(Date:7/31/2020)... ... , ... The SDX® Respiratory Gating System , trusted ... its 20th anniversary of worldwide use. Introduced in the US over the past ... of Pennsylvania, University of Michigan, University of Maryland, University of California San Francisco—and ...
Breaking Biology Technology:
Cached News: