HOME >> BIOLOGY >> NEWS
Scientists explain how morphogens work

CINCINNATI Scientists at Cincinnati Children's Hospital Medical Center believe they have answered some critical questions that address how signaling molecules, called morphogens, work.

Morphogens are secreting signaling molecules that play a key role in the formation of the shape and size of organs. For example, these molecules play a role in determining the bean-like shape of human kidneys. But when these molecules malfunction, they can lead to organ defects and cancers. This study provides insights into the mechanisms of organogenesis and could have implications for treating organ defects and cancers.

For years scientists at Cincinnati Children's and elsewhere have sought to determine how morphogens work. In a new study published in the October 15 issue of the journal Cell, Xinhua Lin, PhD, an assistant professor of developmental biology at Cincinnati Children's, concluded that morphogens work by "diffusion."

"These findings provide new insight into the understanding of the mechanisms that control the function of morphogens," Lin said. "In order to treat diseases related with morphogen malfunctions, scientists must first understand the mechanisms that trigger diseases. This understanding can lead to new insight into the possibility of developing new strategies to treat related diseases."

There are several groups of morphogens, but in his new paper, Dr. Lin focuses on TGF beta family molecules that function as morphogens. His interest is in learning how the TGF beta morphogen works.

Developmental biologists have considered and tested several theories that could explain how morphogens work. These theories include extracellular diffusion and transcytosis. In extracellular diffusion, it is suggested that morphogens move across cells by traveling across the surface of cells. Alternatively, the transcytosis model proposes that cells transfer morphogen molecules through endocytosis, which is the incorporation of s
'"/>

Contact: Amy Reyes
amy.reyes@cchmc.org
513-636-9684
Cincinnati Children's Hospital Medical Center
15-Oct-2004


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... BioCatch , the global leader in behavioral biometrics, reported a ... over 40 granted and pending patents. ... , The Company,s IP portfolio expansion ... Device, and Method Estimating Force Applied to a Touch Surface, " ... components needed to estimate the force and pressure applied to touch surfaces ...
(Date:12/6/2016)... 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... offering of €500.0 million principal amount of its 1.414% senior ... its 2.425% senior unsecured notes due 2026. ... December 13, 2016, subject to the satisfaction of customary closing conditions.  ... The Company intends to use the ...
(Date:12/5/2016)... 5, 2016  The Office of Justice Programs, ... CT Scans Enhance or Replace Medico Legal Autopsies?" ... supporting or replacing forensic autopsies with postmortem X-ray ... In response to recommendations made by The ... CT scans as a potential component of medicolegal ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire-USNewswire/ ... treatments for congestive heart failure and type 2 ... license for a novel adeno-associated virus (AAV) vector ... Kay , M.D., Ph.D., at Stanford University. The ... of its paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... Oxford Gene Technology (OGT), The Molecular ... with the launch of the SureSeq myPanel™ NGS Custom FH ... familial hypercholesterolemia (FH). The panel delivers single nucleotide variation (SNV) ... panel and allows customisation by ,mix and match, of fully-optimised ... LDLR , P C SK9 , ...
(Date:12/8/2016)... ... 08, 2016 , ... This CAST literature review and report looks at problems ... on the economic effects in countries that are major global commodity exporters and importers, ... resultant risk of low level presence (LLP) puts large volumes of trade worth billions ...
(Date:12/8/2016)... Dec. 8, 2016 Eutilex Co. Ltd. today ... (US $18.9M) Series A financing. This financing round included ... Venture and SNU Bio Angel. This new funding brings ... KRW (US $27.7M) since its founding in 2015. ... the development and commercialization of its immuno-oncology programs, expand ...
Breaking Biology Technology:
Cached News: