HOME >> BIOLOGY >> NEWS
Scientists find cell surface enzyme matriptase causes cancer

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) and colleagues report in animal studies that a single, scissor-like enzyme called matriptase, when left to its own devices, can cause cancer.

This finding, published in the current issue of the journal Genes and Development, marks the first report of a protein-cleaving enzyme, or protease, on the cell surface that can efficiently trigger the formation of tumor cells. The authors also note that matriptase is the first known cell-surface protease that can act as an oncogene, an umbrella term for mutated genes and their proteins that prompt cells to divide too rapidly, a hallmark of tumor cells.

"What makes matriptase potentially such a good molecular target to treat cancer is its accessibility," said NIDCR scientist Dr. Thomas Bugge, the senior author on the paper. "We don't have to trick the tumor cell to internalize a drug, then hope it reaches its destination in an appropriate concentration and duration. In this case, the bull's eye is right on the cell surface."

Bugge said the exact function of matriptase in healthy human cells remains a bit of a mystery. Previous studies show that cells comprising the outer lining, or epithelium, of nearly all human organs express the protease. They also suggest that matriptase might play a role in activating other membrane-bound proteins on the cell surface that are involved in signaling basic cellular activities, such as growth and motility.

Since its discovery nearly 13 years ago, scientists also have suspected that matriptase might have a dark side. It is overly abundant in a variety of epithelial-derived tumors, including breast, prostate, ovarian, colon, and oral carcinomas. Then, in 2002, scientists reported women with breast and ovarian cancer have poor prognoses if their tumors contain high levels of matriptase. In fact, just two months ago, researchers reported for the first time that increased
'"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
15-Aug-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... (PRWEB) , ... May 26, ... ... of enterprise software solutions for biopharmaceutical R&D, today announced that Gritstone Oncology, ... T-cell receptor (TCR)-mimetic bispecific T cell engagers and TCR-based therapeutics, has implemented ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... technology-based services specializing in background and medical screening, announces the launch of ... and keeping their workforce safe. The new service is provided by ClearStar’s ...
(Date:5/21/2020)... (PRWEB) , ... May 20, 2020 , ... ... and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health ... & Gene Therapy, will be presenting at the ISCT 2020 Paris Virtual conference, ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... ... May 05, 2020 , ... Smart Meter, a ... iGlucose® LTE Cat-M Cellular Connected Diabetes Blood Glucose Monitor and Remote ... newest and broadest cellular connectivity available, to provide patients with seamless connectivity to ...
(Date:4/22/2020)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announced today that Omixon’s ... Meintjes led the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 ...
(Date:4/7/2020)... Calif. (PRWEB) , ... April 06, 2020 , ... ... their future children, reached 200,000 SneakPeek Early Gender DNA Tests sold in ... SneakPeek was launched as an ecommerce product, where a mom could order her ...
(Date:4/1/2020)... Netherlands (PRWEB) , ... March ... ... Molecular Biology Systems, B.V. (MBS) has developed a method using its revolutionary ... to eight minutes. Combined with smaller reaction volumes, increased samples per run, ...
Breaking Biology Technology:
Cached News: