HOME >> BIOLOGY >> NEWS
Scientists find gene in obese mice that increases type 2 diabetes

MADISON - In a painstaking set of experiments in overweight mice, scientists from the University of Wisconsin-Madison have discovered a gene that appears to play an important role in the onset of type 2 diabetes.

The finding is important because it provides evidence that the same gene in humans could provide clinicians with a powerful tool to determine the likelihood that some individuals will acquire the condition. Moreover, the finding that the gene works through a pathway not generally studied in the context of diabetes, suggests new avenues to explore in the search for new drugs to treat or prevent the disease, says Alan Attie, a UW-Madison professor of biochemistry and the senior author of the study published this week (May 7) in the journal Nature Genetics.

Type 2 diabetes is the most common form of the condition in the United States, with an estimated 16 million Americans afflicted with the disease. It is caused by an inability of the pancreas to produce enough insulin, or by the body's reduced ability to respond to insulin, or both. Insulin is necessary for the body to properly utilize sugar.

Often, the development of type 2 diabetes is caused by obesity. Obese individuals tend to have insulin resistance; that is, it takes more insulin for the body to respond normally. Type 2 diabetes occurs when the pancreas is unable to manufacture enough insulin to compensate for the body's increased demand for the hormone, which it does by growing more insulin-producing beta cells or by ramping up insulin secretion.

The Wisconsin study, comparing two strains of obese mice differing in susceptibility to diabetes, helps explain why this is so.

"Most people who are obese don't have diabetes, but people who are obese are insulin resistant," says Attie. "If there is a fall-off in insulin production, that's when you go from prediabetes to diabetes."

The gene found by Attie's group likely influences the ability of the pancreas to
'"/>

Contact: Alan D. Attie
attie@biochem.wisc.edu
608-262-1372
University of Wisconsin-Madison
7-May-2006


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2020)... (PRWEB) , ... June 11, 2020 , ... ... DNA services, announces a significant expansion of its forensic genealogy team. Bode’s ... and attorneys through proven forensic genealogy and DNA analysis methods. The team has ...
(Date:6/11/2020)... ... , ... Superior Controls, Inc. , an E Technologies Company and leading ... sciences industry, is pleased to announce the recent hiring of Ray Boudreau, who will ... Hampshire office. In his new role, Boudreau will use his extensive experience with ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have ... our attendees, staff, and the public. We remain committed to creating a global ... collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The abstract ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... WESTMINSTER, Colo. (PRWEB) , ... ... ... providers of expert tissue data insights, today announced that the launch of ... PD-L1 results along with data about the tumor microenvironment (TME). , “Flagship’s ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/28/2020)... ... 26, 2020 , ... The Security Industry Association ... opposition to the recently introduced bicameral Facial Recognition and Biometric Technology Moratorium ... use of nearly all biometric and related image analytics technologies, incorrectly labeling all ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... indoor environments, announced today that Derek Fournier has been appointed CEO and President. ... the Board, effective immediately. , “DeCurtis Corporation has been on an incredible ...
Breaking Biology Technology:
Cached News: