Scientists find impaired chromatin structure formation & imprinted gene involvement in Ret...( ns We think that a small difference i...)

ns, "We think that a small difference in the level of proteins in neurons can exert a strong impact on brain function. Most likely, our finding that MeCP2 mutations lead to a loss of imprinting, subsequently resulting in a mild increase in DLX5 expression, represents such an idea. It is likely that MeCP2 has an important function in the fine tuning of the level of key proteins in the brain."

"Loss of silent chromatin looping and impaired imprinting of DLX5 in Rett syndrome," by Shin-ichi Horike, Shutao Cai, Masaru Miyano, Jan-Fang Chen, and Terumi Kohwi-Shigematsu, appears in the January issue of Nature Genetics. The paper is available online at http://www.nature.com/cgi-taf/dynapage.taf?file=/ng/journal/vaop/ncurrent/index.html This work was supported by the National Institutes of Health, the International Rett Syndrome Association and the Rett Syndrome Research Foundation.

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Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
20-Dec-2004

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