HOME >> BIOLOGY >> NEWS
Scientists identify gene involved in stem cell self-renewal in planaria

CHAMPAIGN, Ill. -- No matter how you slice it, the freshwater planarian possesses an amazing ability to regenerate lost body parts. Chop one into pieces, and each piece can grow into a complete planarian. The flatworm relies upon a population of stem cells to accomplish this remarkable feat; recent work sheds light on how planarians maintain these stem cells throughout their lives.

In a paper to appear in the August issue of the journal Developmental Cell, scientists show that a member of the Bruno-like family of RNA binding proteins produced by a gene found in both planarians and humans plays a vital role in maintaining the stem cell population in the planarian Schmidtea mediterranea. The work could lead to a better understanding of the fundamental mechanisms by which stem cells are regulated; such basic understanding is required for the successful therapeutic application of stem cells in humans.

"One of the defining characteristics of stem cells is their ability to self-renew that is, to make more stem cells in addition to differentiating into multiple cell types," said Phillip A. Newmark, a professor of cell and developmental biology at the University of Illinois at Urbana-Champaign and corresponding author of the paper. "We found that in the absence of this protein, the stem cells could respond to wound stimuli, proliferate, and differentiate, but they were unable to self-renew. As a result, the regeneration process failed and the animals died."

Using a technique called RNA interference, Illinois graduate student Tingxia Guo and Newmark first eliminated most of the Bruno-like protein (Bruli) from a number of planarians. Then they amputated a small piece from each flatworm. In the usual manner, the planarian stem cells migrated to the site of the wound, sensed what was missing and began rebuilding. Regeneration ceased, however, when the stem cell population became depleted.

"Had Bruli protein been present, the regeneration process wo
'"/>

Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
7-Aug-2006


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... will be hosting a Webinar titled, “Pathology is going digital. Is your lab ... digital pathology adoption best practices and how Proscia improves lab economics and realizes ...
(Date:10/11/2017)... ... 2017 , ... A new study published in Fertility and ... in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study ... comparing the results from the fresh and frozen transfer cohorts, the authors of ...
(Date:10/10/2017)... ... 10, 2017 , ... For the second time in three ... Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, October ... US2020’s mission is to change the trajectory of STEM education in America by ...
Breaking Biology Technology:
Cached News: