HOME >> BIOLOGY >> NEWS
Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.sciencexpress.org.

"The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic application," says Gary Ruvkun, PhD, of the MGH Department of Molecular Biology, the study's senior author. "Imagine short, double-stranded RNA molecules that could be synthesized quickly and inexpensively to silence a single gene. Promising targets could include viruses like HIV and hepatitis C or cancer-causing oncogenes. An RNAi-based treatment for age-related macular degeneration is already in clinical trials." Ruvkun is a professor of Genetics at Harvard Medical School.

RNAi was originally identified in the C. elegans roundworm and the flowering plant Arabidopsis thaliana, both of which are common model organisms for biological research. The process interrupts the usual transfer of instructions from double-stranded DNA, through single-stranded messenger RNA and finally into proteins. Short, double-stranded pieces of RNA bind to the complementary messenger RNA segments, shutting down gene expression. RNAi occurs naturally in plants and animals and may help control resistance to viral infection, among other functions.

For the current study, lead author John Kim, PhD, and his colleagues developed a strain of C. elegans into which they added a gene that caused the worms to glow under ultraviolet light but also turned that gene off using RNAi. They then used RNAi to inacti
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
24-Mar-2005


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/9/2018)... ... August 08, 2018 , ... Specialty Med ... helps physicians bring the latest regenerative therapies and treatment options to their patients, ... 2018 in White Plains, NY. , The 2-day clinical collaboration ...
(Date:8/7/2018)... ... August 06, 2018 , ... BioMedGPS announces the launch ... Inspired by its medical device customers, BioMedGPS teamed up with a usability expert ... changes, SmartTRAK 3.0 touts a cleaner look, easier navigation and improved functionality. ...
(Date:8/2/2018)... , ... August 02, 2018 , ... ... solutions to pharmaceutical and biotech companies, today announced that Mark Jara, principal of ... inspiring people in the life sciences industry. Individuals named to PharmaVOICE 100 are ...
Breaking Biology News(10 mins):
(Date:8/14/2018)... ... August 14, 2018 , ... The growing interest in ... the Chinese Association of Orthopaedic Surgeons (CAOS) held in partnership with the North ... , Beijing, and Invibio Biomaterial Solutions partnered to demonstrate the new ...
(Date:8/9/2018)... ... August 08, 2018 , ... InTouchMD , the leading provider ... they will be exhibiting at Biotech Week Boston , September 4th – 7th ... Pulse platform, healthcare’s most powerful all in one marketing solution. Pulse is ...
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson Gumpertz ... (AEC) experts with building owners and managers for a full-day discussion on health ... symposium comes to Boston for the first time on Thursday, 13 September 2018, ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading ... covers methods for extracting and using adipose tissue-derived stem cells to treat or ... While this patent covers Canada specifically, VetStem has been issued similar patents ...
Breaking Biology Technology:
Cached News: