HOME >> BIOLOGY >> NEWS
Scientists identify 'missing link' in process leading to Alzheimer's disease

Scientists at the University of Virginia have identified what appears to be a major missing link in the process that destroys nerve cells in Alzheimer's disease, an incurable disease that slowly destroys memory and cognitive abilities. The findings are reported in the Nov. 20, 2006, issue of the Journal of Cell Biology (http://www.jcb.org/cgi/content/full/175/4/541) and could eventually lead to new drugs that target and disrupt specific proteins that conspire in the brain to cause Alzheimer's.

In Alzheimer's disease, two kinds of abnormal structures accumulate in the brain: amyloid plaques and neurofibrillary tangles. The plaques contain fibrils that are made from protein fragments called "beta-amyloid peptides." The tangles also are fibrous, but they are made from a different substance, a protein called "tau." In the new U.Va. study, the researchers found a deadly connection between beta-amyloid and tau, one that occurs before they form plaques and tangles, respectively.

According to George Bloom, the senior author of the study and a professor of biology and cell biology at U.Va., this connection causes the swiftest, most sensitive and most dramatic toxic effect of beta-amyloid found so far. What makes it most remarkable, though, is that it requires a form of amyloid that represents the building blocks of plaques, so called "pre-fibrillar beta-amyloid," and it only happens in cells that contain tau. Even though they account for just ~10 percent of the cells in the brain, nerve cells are the major source of tau, which likely explains why they are specifically attacked in Alzheimer's disease.

The researchers used cultured mammalian cells that either did or did not make tau to study how cells respond to beta-amyloid. They found that pre-fibrillar, but not fibrillar beta-amyloid works together with tau to break apart microtubules highways along which "synapse" replacement parts move rapidl
'"/>

Contact: George Bloom
gsb4g@virginia.edu
434-243-3543
University of Virginia
7-Feb-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 11, 2018 , ... The American College of Medical ... Flatley Brennan, RN, PhD, Director of the National Library of Medicine (NLM), during the ... Annual Symposium is taking place Nov. 3 – 7. , In honor of Morris ...
(Date:10/5/2018)... (PRWEB) , ... October 04, ... ... in partnership with the University of Illinois Extension and Monroe County Economic ... of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) Non-Land Grant ...
(Date:10/3/2018)... ... October 03, 2018 , ... Fit4D, a ... appointment of healthcare visionary, Jimmy Lee, as Strategic Advisor to the company’s board. ... healthcare industry experience. As a Senior Executive at Anthem, he had P&L accountability ...
Breaking Biology News(10 mins):
(Date:10/2/2018)... YORBA LINDA, Calif. (PRWEB) , ... October 02, ... ... culture labs. Undetected or ignored, contamination endangers the reliability and reproducibility of experimental ... prevent microbial contamination. , In this educational webinar, which is sponsored by ...
(Date:9/29/2018)... ... September 29, 2018 , ... ... and early-stage companies to access the power of influence analytics and data-driven engagement ... to a broader market that didn’t necessarily have access to the same financial ...
(Date:9/28/2018)... ... September 28, 2018 , ... LabRoots , the ... scientists from around the world, is excited to announce Daniel Andrade, a 22-year-old ... the winner of the LabRoots Summer 2018 Textbook Scholarship, awarding him $1,000 to ...
(Date:9/27/2018)... ... September 26, 2018 , ... Consumers ... of their primary care physicians, according to a new Zeldis Research and Schlesinger ... doctors were asked about consumer adoption of fitness and health wearables, remote monitoring, ...
Breaking Biology Technology:
Cached News: