HOME >> BIOLOGY >> NEWS
Scientists identify molecule that regulates well-known tumor suppressor

Scientists have discovered that a molecule called DJ-1 is likely to be involved in the generation of human tumors through negative regulation of the well-known tumor suppressor, PTEN. The research, published in the March issue of Cancer Cell, has important implications for determining the prognosis of some human cancers, and may prove to be a suitable target for cancer therapy.

The phosphatidylinositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB/Akt signaling that is critical for cell survival. Many human cancer cells exhibit mutations in the PTEN gene, but other cancers have the normal PTEN gene. While it is clear that without normal PTEN there is a loss of PKB/Akt inhibition that can lead to tumor growth, sometimes cancers with normal PTEN also exhibit abnormally high levels of PKB/Akt activity. In a quest to determine what molecules regulate normal PTEN, Dr. Tak W. Mak from the Ontario Cancer Institute and the University of Toronto and colleagues used a genetic screening method in fruit flies and identified the molecule DJ-1 as a PTEN suppressor.

In studies with mammalian cells, low levels of DJ-1 correlated with decreased PKB/Akt activity, while increased DJ-1 led to activation of PKB/Akt and enhanced cell survival. In cancer cells from breast cancer patients, elevated PKB/Akt activity and reduced PTEN expression were associated with elevated DJ-1levels. DJ-1 levels were increased in cells from lung cancer patients, and DJ-1 was associated with poor prognosis.

"Our results demonstrate that DJ-1 negatively regulates PTEN function, and that this cell survival control mechanism is conserved among various tissues and species. Taken together, our data suggest that overexpression of DJ-1 can modulate PTEN tumor expression to the point where oncogenesis may result from upregulat
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
14-Mar-2005


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/29/2018)... PRUSSIA, Pa. (PRWEB) , ... November 29, 2018 ... ... equity investment in Semba Biosciences with the intention of acquiring full ownership. The ... Equity Participation Agreement was executed on November 14, 2018. “We are extremely pleased ...
(Date:11/27/2018)... , ... November 27, 2018 , ... ... cryogenics industry a sealing solution with a broader range of usage temperature compared ... PEEK expert will introduce its new VICTREX CT™ 200 for dynamic sealing applications ...
(Date:11/20/2018)... (PRWEB) , ... November 19, 2018 , ... Cloudponics ... system for the home, today announced a discount of $420 for its industry-leading product ... $2690 GroBox if paid in full, with other discount and payment options available on ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ... ... The incredible life story of former refugee and LG Sonic CEO Yousef ... the European Commissioner for Research and Innovation. , In his November 27th speech ... spoke at length of Yousef’s life and journey, citing the man who convinced him ...
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's ... as well as experience the height of truffle season. , Her first ... pristine countryside. Staying in the exclusive Black Truffle Lodge in the small mountain village ...
(Date:11/20/2018)... ... , ... Patients with missing teeth in Sandy Springs, GA, Alpharetta, GA, and ... at THE DENTIST Centers without a referral. Dr. Myers is a skilled cosmetic dentist ... He now offers skilled dental care in two practice locations THE DENTIST Windward Parkway ...
(Date:11/13/2018)... POWAY, Calif. (PRWEB) , ... November 13, 2018 , ... ... to patients on the island of Kauai. Dr. Leadbeater, of Kahala ... cell services since 2009. Recently, he began traveling to the island of Kauai ...
Breaking Biology Technology:
Cached News: