HOME >> BIOLOGY >> NEWS
Scientists identify new model Of NK cell development

COLUMBUS, Ohio - Scientists here have made a major discovery that sheds new light upon the growth and development of human natural killer (NK) cells, powerful but somewhat mysterious components of the body's immune system that are the first line of defense against cancer and infectious diseases.

Scientists have believed for years that human NK cells are generated in bone marrow, but Michael Caligiuri, director of the OSU Comprehensive Cancer Center and the senior author of the study, says research in his laboratory shows that the precursors to NK cells are actually found in cellular nurseries deep inside the body's lymph nodes.

The findings, appearing in the Mar. 22 issue of the journal Immunity, may offer clinicians new direction in determining how to manipulate this cell type in enhancing immune responses to cancer.

"This study is fundamentally about understanding the immune system more fully so we can help patients," says Caligiuri.

A major arm of the body's defense system is made up of lymphocytes, cells that fall broadly into three categories T cells, B cells and NK cells.

Although all lymphocytes stem from a common source progenitor cells in the bone marrow they take different paths in developing into full-fighters in the immune system. For example, cells destined to become T cells, sophisticated and highly focused killer cells, are released into the bloodstream and migrate to the thymus where they learn their role. In contrast, B cells, which make antibodies, remain and mature in the bone marrow. Until now, scientists thought NK cells did the same.

But Caligiuri, working with Aharon Freud, the lead author of the study and a doctoral candidate in Caligiuri's laboratory, had noted other work showing that mice lacking lymph nodes also lacked NK cells. In addition, in earlier research in Caligiuri's laboratory, scientists had identified two distinct subsets of human NK cells (referred to as CD56 bright and CD56 d
'"/>

Contact: Michelle Gailiun
gailiun.1@osu.edu
614-293-3737
Ohio State University
22-Mar-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... ... ... Throughout the month of October, consumers will see thousands of their favorite ... industry expert David Carter is available to explain why so many leading brands and ... demand for non-GMO foods and beverages is gathering momentum, as consumers want to know ...
(Date:9/25/2017)... ... September 25, 2017 , ... Comprehend, ... presentations and demonstrations at SCDM 2017, held September 24-27, 2017 in Orlando. ... and CRO partners for more automated capabilities across evolving data, Comprehend delivers ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... venous leg ulcers is now being assessed in clinical trials in the United ... please talk to your nurse or physician or find your nearest participating clinic ...
(Date:9/21/2017)... ... September 21, 2017 , ... Executives and subject ... most progressive pharma and biotech organizations to do more clinical trials will share ... events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s first unified ...
Breaking Biology Technology:
Cached News: