HOME >> BIOLOGY >> NEWS
Scientists identify new model Of NK cell development

im cells) and they observed that the bright subset appeared much more frequently in lymph nodes than in bone marrow or circulating blood.

In other words, they had a hunch traditional thinking about the origin of human NK cells might be wrong.

In building a case to support their beliefs, they first identified the NK precursor cell, then, they measured the number of the precursors in different parts of the body. Through flow cytometry, they discovered that while NK precursors make up about 1 percent of bone marrow progenitor cells and 6 percent of circulating blood progenitor cells, they comprise virtually all of the progenitor cells found in lymph nodes.

Interestingly, Gerard Nuovo, a pathologist and co-author of the study, discovered that these novel NK precursor cells are not randomly strewn throughout the lymph nodes, but rather localized near special sites called parafollicular regions, rich in T cells and NK bright cells.

"We thought this was pretty interesting because we know that in order for these NK precursor cells to grow and differentiate, they need one of two cytokines, interleukin-2 or interleukin-15," says Freud. "So it may not be coincidental that two types of immune cells that make those substances T cells and dendritic cells just happen to reside in lymph nodes, too."

Freud also makes the provocative observation that lymph nodes, while full of CD56 bright cells, are significantly lacking in their counterparts, the CD56 dim cells.

"Our next goal is to determine if there is some developmental continuum at work here, supporting the notion that CD56 bright cells are really just immature CD56 cells," he adds.

"This study raises almost as many questions as it answers," says Caligiuri, "Finding these nursery sites of NK cells is just the first step. We feel this is the first solid evidence supporting a new model of NK cell development, but we also know that more work needs to be done to fill in so
'"/>

Contact: Michelle Gailiun
gailiun.1@osu.edu
614-293-3737
Ohio State University
22-Mar-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
Breaking Biology News(10 mins):
(Date:5/29/2017)... ... May 29, 2017 , ... ... of the Year by the International Business Innovation Association and the Milken Institute ... accolades underscore what business leaders in and out of Greater Gainesville already know: ...
(Date:5/26/2017)... ... May 25, 2017 , ... Studying biological ... each occurrence. Live cell imaging using fluorescence microscopy is the perfect approach to ... fluorescence microscopy methods will be discussed, from small animal models and tissues to ...
(Date:5/24/2017)... Utah (PRWEB) , ... May 24, 2017 , ... ... the selection and implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) ... key component of a $24 million plant upgrade to sustainably meet current and ...
(Date:5/24/2017)... ... May 24, 2017 , ... Patient Monitoring and Diagnostic ... connectivity to reduce the amount of wiring in a healthcare facility and allow ... devices including infusion pumps, heart and hypertension monitoring, glucose monitoring, and other wearable ...
Breaking Biology Technology:
Cached News: