HOME >> BIOLOGY >> NEWS
Scientists identify new model Of NK cell development

im cells) and they observed that the bright subset appeared much more frequently in lymph nodes than in bone marrow or circulating blood.

In other words, they had a hunch traditional thinking about the origin of human NK cells might be wrong.

In building a case to support their beliefs, they first identified the NK precursor cell, then, they measured the number of the precursors in different parts of the body. Through flow cytometry, they discovered that while NK precursors make up about 1 percent of bone marrow progenitor cells and 6 percent of circulating blood progenitor cells, they comprise virtually all of the progenitor cells found in lymph nodes.

Interestingly, Gerard Nuovo, a pathologist and co-author of the study, discovered that these novel NK precursor cells are not randomly strewn throughout the lymph nodes, but rather localized near special sites called parafollicular regions, rich in T cells and NK bright cells.

"We thought this was pretty interesting because we know that in order for these NK precursor cells to grow and differentiate, they need one of two cytokines, interleukin-2 or interleukin-15," says Freud. "So it may not be coincidental that two types of immune cells that make those substances T cells and dendritic cells just happen to reside in lymph nodes, too."

Freud also makes the provocative observation that lymph nodes, while full of CD56 bright cells, are significantly lacking in their counterparts, the CD56 dim cells.

"Our next goal is to determine if there is some developmental continuum at work here, supporting the notion that CD56 bright cells are really just immature CD56 cells," he adds.

"This study raises almost as many questions as it answers," says Caligiuri, "Finding these nursery sites of NK cells is just the first step. We feel this is the first solid evidence supporting a new model of NK cell development, but we also know that more work needs to be done to fill in so
'"/>

Contact: Michelle Gailiun
gailiun.1@osu.edu
614-293-3737
Ohio State University
22-Mar-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... , March 27, 2017 Neurotrope, ... novel therapies for neurodegenerative diseases, including Alzheimer,s disease, ... its application to list the Company,s common stock ... by The NASDAQ Stock Market, a unit of ... listing, Neurotrope will ring the Opening Bell at the ...
(Date:3/24/2017)... DUBLIN , Mar. 24, 2017 Research ... Stem Cell (hESC) Research - Global Strategic Business Report" report ... ... Cell (hESC) Research in US$ Million. Annual estimates and forecasts are ... are derived from primary and secondary research. The ...
(Date:3/24/2017)...   Sienna Biopharmaceuticals, Inc. , a privately held, ... Richard Peterson will join the company as ... who brings more than two decades of global financial ... retiring at the end of April but will continue ... Sienna from Novan, Inc., where he served as Chief ...
(Date:3/23/2017)... , ... March 23, 2017 , ... Lajollacooks4u is proud to announce it has become ... hosted corporate cooking challenges for companies around the world, such as Illumina, HP and Qualcomm, ... the reason for its increasing popularity is due to its new team building format, a ...
Breaking Biology Technology:
Cached News: