HOME >> BIOLOGY >> NEWS
Scientists link another gene to degenerative blindness

Researchers have labored for decades to understand blindness-inducing neurodegenerative diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP).

It has been a painstaking scientific journey as AMD and RP each belong to a complex family of disorders, in which every disorder has many forms and each form is encoded with a distinct genetic recipe. Even AMD, a major cause of vision loss in people over 60, is actually a collection of more than 50 diseases.

Now, a team of researchers at the University of Wisconsin-Madison has taken a small but crucial step forward in the ongoing fight against retinal degeneration. Working with fruit flies, the scientists have discovered that a mutation in a common gene called calnexin can derail the light-processing activity of cells and set in motion the gradual breakdown of vision. They report their findings today in the journal Neuron.

Calnexin-found in both fruit flies and humans-functions as a cellular chaperone, ensuring that proteins "fold" or orient properly and get to the parts of the cell they need to go. It also modulates calcium levels, which is critical for proper vision.

When calnexin goes awry, however, calcium levels build up and the proteins that depend on it malfunction, says senior author Nansi Jo Colley, a medical geneticist at the UW-Madison departments of ophthalmology and genetics, and an affiliate of the Eye Research Institute.

At a time when more than 103 genes are known to be involved with AMD and RP, the UW-Madison work could one day help doctors deliver tailor-made treatments to patients who specifically carry calnexin mutations. Because the calnexin protein and other chaperones are also present in the brain, the work can help to answer broader questions about neurodegenerative disease, Colley adds.

"Understanding the basic mechanisms of how proteins are folded holds the key to finding treatments for not only retinal degenerative diseases but also ot
'"/>

Contact: Nansi Jo Colley
njcolley@wisc.edu
608-265-5398
University of Wisconsin-Madison
18-Jan-2006


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... ... customer, will deliver a joint presentation with Versiti’s CIO at the Healthcare ... the Rosen Shingle Creek Resort. , Versiti Vice President and Chief Information Officer, ...
(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its ... Spine, Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at ... Wacker Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. ...
(Date:6/11/2019)... Zealand (PRWEB) , ... June 12, 2019 , ... ... range of antibody discovery services, Abveris plans to leverage the Geneious Biologics platform ... Dr. Colby Souders, Chief Technology Officer at Abveris, says: “The Geneious team has ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a leading ... space from 2,500 to 5,000 square feet. , “This past year has seen ... says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:5/2/2019)... BOSTON (PRWEB) , ... May 02, 2019 , ... ... hair transplantation clinic in the greater Boston area. Gone are the days of ... The ARTAS® iX Robotic Hair Restoration System is the only robotic intelligent solution ...
Breaking Biology Technology:
Cached News: