HOME >> BIOLOGY >> NEWS
Scientists move closer to bio-engineered bladders

Researchers at the University of York are using an understanding of the special cells that line the bladder to develop ways of restoring continence to patients with serious bladder conditions, including cancer. The research, highlighted in the quarterly magazine of the Biotechnology and Biological Sciences Research Council (BBSRC) this week, is looking at urothelial cells. These are the specialised lining cells of the bladder that enable it to retain urine. The cells have a very low turnover rate, but scientists have found that if the bladder is damaged, the urothelial cells are able to rapidly re-grow to repair the wound. The researchers hope to harness this property to engineer new bladders.

The York researchers have developed a series of models that mean they can study human urothelial cells in the laboratory. Of these models, the most important is their development of a urothelial cell sheet that functions as it would in the bladder. When the researchers create a wound in this model, the cells regenerate to repair the damage - just as they would in the body.

Pharmaceutical companies should soon be able to use the research models to test therapies for the bladder, but the longer term aim for this research is to help patients who have lost bladder function or have had all or part of their bladder removed because of cancer.

Research leader, Professor Jenny Southgate, explains: "The models we have developed mean that we have been able to examine how urothelial cells in the bladder self-renew to cope with injury.

"With this basic understanding of how the cells work, we are moving towards being able to engineer new bladders. Currently, substitute bladders can be created by using a section of the patient's bowel, but this can lead to complications, as the bowel does not have the same urine-holding properties as urothelial cells. One solution could be to use laboratory-grown urothelial cells to line a section of bowel."


'"/>

Contact: Matt Goode
press.office@bbsrc.ac.uk
01-793-413-299
Biotechnology and Biological Sciences Research Council
31-Jul-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists find stem cell switch
4. Scientists discover new way to study nanostructures
5. Scientists a step closer to understanding how anaesthetics work in the brain
6. Scientists to make news at Computational Biology Conference
7. Accident-prone? Scientists link brain function to knee injuries
8. Scientists take next step in understanding potential target for ovarian cancer treatment
9. Scientists find brown fat master switch
10. Scientists identify 2 distinct Parkinsons networks
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2019)... ... November 07, 2019 , ... R3 Stem Cell is ... through the rest of 2019. The code to use during checkout is FIFTYOFF and ... R3 is the nation’s leader in regenerative therapies with over 12,000 successful stem cell ...
(Date:11/5/2019)... ... November 05, 2019 , ... Catalent, the leading ... gene therapies, and consumer health products, today announced it will present at the ... on Nov. 12 – 14, 2019. , On Wednesday, Nov. 13 at 3:20 ...
(Date:10/30/2019)... ... October 29, 2019 , ... LGC Maine Standards releases ... Order Numbers 701sa & 704sa. The kits, in a human-urine matrix, evaluate CA, ... Each VALIDATE® kit, liquid, ready-to-use, and prepared using the CLSI EP06-A “equal delta” ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... they have been selected by Lantern Pharma to provided preclinical screening and drug ... millions of data points using panels of unique and genetically edited cell lines ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , a ... Genedata Biologics® to streamline their R&D operations related to the discovery ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... for the food and beverage industry launched a new innovative website. , After ... experience. Now, the website offers global visitors updated ingredient usage tables by food ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... their new Director of Forensic Genealogy, Melinde Lutz Byrne, to the organization. Byrne’s ... to ultimately provide investigative leads to law enforcement through proven genealogy and DNA ...
Breaking Biology Technology:
Cached News: