HOME >> BIOLOGY >> NEWS
Scientists move closer to bio-engineered bladders

Researchers at the University of York are using an understanding of the special cells that line the bladder to develop ways of restoring continence to patients with serious bladder conditions, including cancer. The research, highlighted in the quarterly magazine of the Biotechnology and Biological Sciences Research Council (BBSRC) this week, is looking at urothelial cells. These are the specialised lining cells of the bladder that enable it to retain urine. The cells have a very low turnover rate, but scientists have found that if the bladder is damaged, the urothelial cells are able to rapidly re-grow to repair the wound. The researchers hope to harness this property to engineer new bladders.

The York researchers have developed a series of models that mean they can study human urothelial cells in the laboratory. Of these models, the most important is their development of a urothelial cell sheet that functions as it would in the bladder. When the researchers create a wound in this model, the cells regenerate to repair the damage - just as they would in the body.

Pharmaceutical companies should soon be able to use the research models to test therapies for the bladder, but the longer term aim for this research is to help patients who have lost bladder function or have had all or part of their bladder removed because of cancer.

Research leader, Professor Jenny Southgate, explains: "The models we have developed mean that we have been able to examine how urothelial cells in the bladder self-renew to cope with injury.

"With this basic understanding of how the cells work, we are moving towards being able to engineer new bladders. Currently, substitute bladders can be created by using a section of the patient's bowel, but this can lead to complications, as the bowel does not have the same urine-holding properties as urothelial cells. One solution could be to use laboratory-grown urothelial cells to line a section of bowel."


'"/>

Contact: Matt Goode
press.office@bbsrc.ac.uk
01-793-413-299
Biotechnology and Biological Sciences Research Council
31-Jul-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists find stem cell switch
4. Scientists discover new way to study nanostructures
5. Scientists a step closer to understanding how anaesthetics work in the brain
6. Scientists to make news at Computational Biology Conference
7. Accident-prone? Scientists link brain function to knee injuries
8. Scientists take next step in understanding potential target for ovarian cancer treatment
9. Scientists find brown fat master switch
10. Scientists identify 2 distinct Parkinsons networks
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2019)... ... November 20, 2019 , ... BioInformatics Inc., part of Science and Medicine Group, ... the winners of the Life Science Industry Awards for the most innovative new products ... – Innovation: , Most Innovative New Product – Cell Biology, ...
(Date:11/19/2019)... ... 2019 , ... The inaugural Cell & Gene Therapy Day takes place February ... event will be chaired by Dr Aiman Shalabi, VP R&D, Cell and Gene Therapies ... are witnessing significant innovation in cell and gene therapies, and we are at a ...
(Date:11/14/2019)... (PRWEB) , ... November 13, 2019 , ... Personalized ... the first patients in an FDA approved clinical trial for stem cell treatment ... the formation of the company as a subsidiary of VetStem Biopharma. , In July ...
Breaking Biology News(10 mins):
(Date:12/6/2019)... ... December 06, 2019 , ... Southern ... for its latest CAPERE® Thrombectomy System for peripheral vascular, deep vein thrombosis ... benefits for first-in-line treatment for nonsurgical removal of soft emboli and thrombi ...
(Date:12/4/2019)... , ... December 03, 2019 , ... ... products and services, today announced a partnership with the Recombinant Antibody Network (RAN), ... Toronto, and UC San Francisco (UCSF) with a common goal to generate recombinant ...
(Date:12/4/2019)... ... December 03, 2019 , ... A new study released today in STEM CELLS ... reverse fibrosis (scar tissue) buildup – also improves the range of motion of the ... conducted on mice. , The tumor-destroying capabilities of radiation therapy can be a ...
(Date:12/4/2019)... , ... December 04, 2019 , ... The technology at ... a human hair, but its potential impact on the pharmaceutical industry could be massive. ... of biological and chemical engineering at South Dakota School of Mines & Technology ...
Breaking Biology Technology:
Cached News: