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Scientists see DNA get 'sunburned' for the first time

damaged depends on the position of the DNA during the extremely brief time required for it to absorb UV light. Either two thymine bases are lined up in just the right way to bond when the UV hits, or they're not.

"This insight explains why some pairs of thymine bases get damaged more frequently than others, and it suggests that scientists can understand damage patterns to DNA by studying the factors that influence how the bases are arranged in space," Kohler said.

"In our efforts to understand photo-damage, this new result shifts our attention to the DNA structure, and the kinds of arrangements that exist at the moment DNA absorbs light."


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Contact: Bern Kohler
Kohler@chemistry.ohio-state.edu
614-688-3944
Ohio State University
1-Feb-2007


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