HOME >> BIOLOGY >> NEWS
Scientists streamline method for making key virus

MADISON -- By devising a novel way to package the genome of a common human tumor virus -- the virus that causes common warts, genital warts and that is implicated in prevalent cancers -- scientists have paved the way for making the pathogen far more accessible to biomedical science.

The work, reported today (June 13) in the online edition of the Proceedings of the National Academy of Science (PNAS), promises to accelerate the search for an effective cancer vaccine and treatments for cervical, head, neck and some skin cancers.

The new study on human papillomavirus by a team of scientists from the Howard Hughes Medical Institute, the Institute for Molecular Virology and the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison, describes a method for making large quantities of the virus in the lab.

The feat could help scientists overcome long-standing hurdles to understanding the basic biology of a major human pathogen: how the virus replicates, infects host cells and evades the immune system. It also promises to speed development of therapeutic drugs and new vaccines, including live, attenuated vaccines, according to Dohun Pyeon, the lead author of the report.

"This new approach offers dramatic advantages," says Paul Ahlquist, a UW-Madison virologist and the senior author of the PNAS paper. "It increases virus yield over a thousand fold, speeds production ten-fold, and lets us make and test virus mutants that weren't possible before."

Papillomavirus can be transmitted non-sexually, but is also one of the most common sexually transmitted diseases in humans, with more than 5 million new infections reported each year in the United States alone. It is perhaps best known as the cause of genital warts, although some forms of the more than 100 subtypes of the virus are known to cause cervical cancer, and cancers of the head, neck and skin.

In nature, the virus lurks in skin cells, where it uses a "stealth strategy" t
'"/>


13-Jun-2005


Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/12/2019)... ... April 11, 2019 , ... Zen Nutrients, a visionary ... help decrease opioid abuse by offering over-the-counter vitamin and supplement assistance to qualified ... to 50% off. , In 2019, Zen Nutrients committed to donate up to ...
(Date:4/9/2019)... FLORENCE, S.C. (PRWEB) , ... April 09, 2019 , ... ... Novalis Certified Cancer Center following a rigorous and voluntary audit conducted by ... , One of only eight Novalis Certified Centers in the United States, McLeod is ...
(Date:4/4/2019)... ... April 02, 2019 , ... Orbsen Therapeutics, a ... immunotherapies, announced it will move its base of operations from the National University ... newly created biotechnology park in Galway, Ireland. , “With four clinical trials in ...
Breaking Biology News(10 mins):
(Date:4/12/2019)... ... April 12, 2019 , ... An ... and will educate about innovative tools and devices being used to enhance cognitive ... more information. , This segment of Advancements will focus on Sound for Life, ...
(Date:4/9/2019)... ... ... The American Society of Gene & Cell Therapy (ASGCT) is ... addition to the presidential line of succession, at the 22nd Annual Meeting . ... for a three-year term (2019-2021). , All five incoming members of the ASGCT ...
(Date:4/4/2019)... ... April 03, 2019 , ... ... intimate off-the-record collaboration and dialogue, today announces its Boston CEO conference to be ... into the industry’s challenges and opportunities with high-level panels and discussions from past, ...
(Date:3/23/2019)... ... March 22, 2019 , ... ... and analysis to a team of researchers at Nnamdi Azikiwe University in Anambra ... Nneka R. Agbokoba, PhD, of the Department of Medical Laboratory Sciences and Deputy ...
Breaking Biology Technology:
Cached News: