HOME >> BIOLOGY >> NEWS
Scientists take next step in understanding potential target for ovarian cancer treatment

A traffic cop protein in the cell may have an even more important role: transporting a messenger protein that tells components in the nucleus to stop cell growth. The discovery of this additional role may lead to diagnostic tools and earlier treatments for ovarian cancer.

A Penn State College of Medicine research team, led by Kathleen M. Mulder, Ph.D., professor of pharmacology, is studying the normal function of a protein called km23, the traffice cop protein, because the team previously found altered forms of the protein in 42 percent of tumor tissue samples taken from women with ovarian cancer.

No similar alterations were found in normal human tissues, suggesting that the km23 alterations may be a possible diagnostic indicator for development of ovarian cancer and that the km23 protein itself may be a possible target for cancer therapies.

km23 is part of the signaling system for a growth factor called TGF, which attaches to TGF receptors at the cell membrane. It activates km23 into action.

km23 acts like a traffic cop for specific proteins as they move in the cell on a highway called a microtubule. It is responsible for helping to match the right cellular cargo with the right motor complex to get the cargo to the correct destination when its needed. One of those precious cargoes is a TGF-signaling component that must get to the cell nucleus to turn on specific genes that help stop cell growth.

Alterations in the TGF signaling system are known to contribute to cancer, Mulder said. We have been searching for new components of this signaling system to determine whether they are also altered in cancer and contribute to its development. These components can then be used to design new treatment strategies for cancer once we understand how they normally function.

In the current study, Mulders team found that blocking km23 from doing its job in the TGF- signaling system disrupted the transport of the sig
'"/>

Contact: Megan Manlove
mmanlove@hmc.psu.edu
717-531-8606
Penn State
16-Jul-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists find brown fat master switch
10. Scientists identify 2 distinct Parkinsons networks
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... March 13, 2020 , ... According to the American Academy ... and possibly be transmitted by aerosol or direct contact with the conjunctiva, the ... special precautions to avoid contracting the coronavirus. Touching the eyes while inserting contact ...
(Date:3/11/2020)... SANTA CLARA, Calif. (PRWEB) , ... March 11, ... ... in IoT solutions for wireless sensing, today announced smart human body temperature infrared ... big data based self-calibrated thermal meter WxS x800-IRTM, supporting flexible wireless uplink for ...
(Date:3/5/2020)... ... March 05, 2020 , ... With numerous products in ... GmbH to accelerate Cytonus’ existing products and to expand the companies’ intellectual property ... a biotech company located in Austria. , Phoenestra has developed IP assets ...
Breaking Biology News(10 mins):
(Date:3/12/2020)... ... March 12, 2020 , ... ... microscopy (AFM) technology, increases the business investment in Europe by inaugurating a new ... Grand Opening Ceremony of the new Nanoscience Center Europe took place Tuesday, February ...
(Date:3/10/2020)... ... March 10, 2020 , ... ... pleased to announce the addition of Carson Dickey to its growing engineering ... in the biopharmaceutical cold chain. He provides design and validation engineering services ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... provider of recombinant antibody products and services, today announced the launch of ... to rapidly express a large number of antibodies at 80 ml scale. ...
(Date:3/3/2020)... ... March 03, 2020 , ... ... biotech and medical device industries, was recognized by INC. 5,000 on an annual ... lists to note industry leaders greatly impacting their spheres of influence and experiencing ...
Breaking Biology Technology:
Cached News: