HOME >> BIOLOGY >> NEWS
Scientists take next step in understanding potential target for ovarian cancer treatment

naling component to the nucleus. Ultimately, this resulted in degradation of the signaling component and reduced gene expression in the nucleus.

The study findings were published recently in The Journal of Biological Chemistry http://www.jbc.org/cgi/reprint/282/26/19122.

The team can use the results of this kind of disruption of normal km23 function for clues about what might happen to the protein in ovarian cancer cells. Then, drug development, targeting the irregular function of the protein, can begin.

Our studies provide a better understanding of how the protein works, what it does, and how its functions may be altered in cancer cells. This leads us to the critical next step -- the design of drugs that can repair the defect in the cancer cells without interrupting the processes of the normal cell, Mulder said. When you find something that isnt working right in the cancer cells, it suggests possibilities as to how to intervene to fix the problem.

Epithelial ovarian cancer is often diagnosed at an advanced stage and accounts for about 15,000 deaths each year. Despite advances in surgical techniques and chemotherapy, overall survival rates have not improved significantly because of late detection, often after the disease has already spread to remote organs. Identification of an early warning signal and a new therapeutic agent for the disease should lead to improved survival rates.


'"/>

Contact: Megan Manlove
mmanlove@hmc.psu.edu
717-531-8606
Penn State
16-Jul-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists find brown fat master switch
10. Scientists identify 2 distinct Parkinsons networks
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/28/2020)... Switzerland (PRWEB) , ... June ... ... provider of enterprise software solutions for biopharmaceutical R&D, today announced that it ... company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... software and software-driven clinical data services that accelerate drug development, is collaborating with ... an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the first ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... BOWLING GREEN, Ohio (PRWEB) , ... June 29, ... ... cooperative that offers access to competitively procured purchasing contracts to its membership, recently ... BioFit to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a ... Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with ... , A Safe Space™ enabled business will provide a health performance index system that ...
(Date:6/28/2020)... ROCKY HILL, Conn. (PRWEB) , ... June 25, ... ... systems company formed to advance photodynamic therapy for treating cancer, today announced the ... Buffalo, New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights ...
(Date:6/23/2020)... ... June 23, 2020 , ... Kerafast Inc. , ... today announced the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. ... studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level ...
Breaking Biology Technology:
Cached News: