HOME >> BIOLOGY >> NEWS
Scientists uncover secret to sharp teeth

A new research study published in the November issue of Developmental Cell identifies a molecular mechanism that controls the precise patterning of enamel formation on incisor teeth. Mouse incisors are covered with enamel on the side closest to the lip while the side facing the tongue remains enamel-free. This irregular distribution of enamel helps to keep the cutting edges of the incisors very sharp. While it is well established that cells called ameloblasts secrete enamel, the molecular signals regulating asymmetric ameloblast differentiation from the underlying dental epithelium are not well understood.

Dr. Irma Thesleff and colleagues from the Institute of Biotechnology at the University of Helsinki examined the contribution of a gene called follistatin to the process of tooth development. Follistatin plays a critical role in the patterning of several organs during embryogenesis. The researchers found that follistatin was expressed at low levels in active ameloblasts and at much higher levels in the dental epithelial cells lining the enamel-free surface of the incisors. Mice engineered to lack follistatin had functional ameloblasts on the normally enamel-free surface adjacent to the tongue. Further investigation revealed that follistatin prevents enamel formation by inhibiting BMP signaling molecules that are potent stimulators of ameloblast differentiation.

The researchers conclude that asymmetric expression of follistatin accounts for the distinct patterning of enamel formation in mouse incisors and that follistatin expression is required for formation of enamel-free tooth regions. While the mechanism that dampens follistatin expression in unknown, it is clear that the lack of follistatin allows BMP signals to stimulate ameloblast differentiation on the labial side of the incisor.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
8-Nov-2004


Page: 1

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... Executives ... the world’s most progressive pharma and biotech organizations to do more clinical trials ... and biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s ...
(Date:9/21/2017)... DIEGO, CALIF. (PRWEB) , ... September 21, 2017 , ... ... earlier this month. The organization, a worldwide society of professional women with high ... venue to hold its annual dinner. , Twelve members began with an ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... appointed Vishwas Paralkar to the role of chief scientific officer. In this role, ... report to Cybrexa’s president and CEO, Per Hellsund. , “I was impressed with ...
(Date:9/20/2017)... ... September 20, 2017 , ... Proscia Inc. ... , a provider of whole slide imaging solutions, are hosting a pre-conference workshop ... entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” will feature Proscia CEO, ...
Breaking Biology Technology:
Cached News: