HOME >> BIOLOGY >> NEWS
Scientists uncover secret to sharp teeth

A new research study published in the November issue of Developmental Cell identifies a molecular mechanism that controls the precise patterning of enamel formation on incisor teeth. Mouse incisors are covered with enamel on the side closest to the lip while the side facing the tongue remains enamel-free. This irregular distribution of enamel helps to keep the cutting edges of the incisors very sharp. While it is well established that cells called ameloblasts secrete enamel, the molecular signals regulating asymmetric ameloblast differentiation from the underlying dental epithelium are not well understood.

Dr. Irma Thesleff and colleagues from the Institute of Biotechnology at the University of Helsinki examined the contribution of a gene called follistatin to the process of tooth development. Follistatin plays a critical role in the patterning of several organs during embryogenesis. The researchers found that follistatin was expressed at low levels in active ameloblasts and at much higher levels in the dental epithelial cells lining the enamel-free surface of the incisors. Mice engineered to lack follistatin had functional ameloblasts on the normally enamel-free surface adjacent to the tongue. Further investigation revealed that follistatin prevents enamel formation by inhibiting BMP signaling molecules that are potent stimulators of ameloblast differentiation.

The researchers conclude that asymmetric expression of follistatin accounts for the distinct patterning of enamel formation in mouse incisors and that follistatin expression is required for formation of enamel-free tooth regions. While the mechanism that dampens follistatin expression in unknown, it is clear that the lack of follistatin allows BMP signals to stimulate ameloblast differentiation on the labial side of the incisor.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
8-Nov-2004


Page: 1

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists uncover secret sharp teeth

(Date:3/24/2015)... GARDENS, Fla. , March 24, 2015 /PRNewswire/ ... identity management solutions, today announced that its U.are.U ... clothing accessory retailer Goorin Bros . to ... Crossmatch biometrics-based solution secures access to the POS ... the increased risk of data breaches. ...
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
(Date:3/18/2015)... As mobile payments become more prevalent ... and apps continue to be introduced into the market place ... payment industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... BABA ), Apple Inc. (NASDAQ: AAPL ), Google ... FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
(Date:3/26/2015)... "In America," the popular news television program that airs in ... legendary film actor James Earl Jones, has announced that it ... , Botany is commonly described as the scientific study ... bit more complicated than that. Scientists and other professionals study ... the smallest bacteria known to man to the largest trees ...
(Date:3/25/2015)... 26, 2015 Agnition announced today that ... American Farmer, airing for the first time at 7:30 ... American Farmer will explore the extremely important role soil ... with a patented Microbial Catalystâ„¢ technology that enhances soil ... The segment will air again on April 28. , ...
(Date:3/25/2015)... , March 25, 2015  S&P Capital ... Factual Stock Report coverage on Abattis Bioceuticals ... ATTBF; CSE: ATT): is a specialty biotechnology company ... cultivating, licensing and marketing proprietary ingredients, bio-similar compounds, ... in North America . The ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 An increase ... ingredients in all forms of food nutrients, regulatory changes ... a substantial rise in demand for natural astaxanthin over ... started to ramp up their capacities to satisfy the ... natural and synthetic source astaxanthin (used in nutraceuticals, aqua ...
Breaking Biology Technology:Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2
Cached News: