HOME >> BIOLOGY >> NEWS
Scientists use gene transfer technology and common virus to block neuropathic pain

ANN ARBOR, Mich. Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it.

It's called neuropathic pain, and it's a common complication of many diseases and medical conditions, especially diabetes. Drugs have little effect on this type of pain, which is caused by damage to sensory neurons that transmit pain, temperature and touch signals to and from the brain.

Now, scientists at the VA Ann Arbor Healthcare System and the University of Michigan Medical School have developed a way to block the signals responsible for neuropathic pain. The secret to their success is based on a virus called herpes simplex or HSV the same virus that causes cold sores and genital herpes. The scientists use a disabled form of the virus, called a vector, to deliver genes to the nucleus of neural cells.

A study published today in the June, 2005 of the Annals of Neurology describes how laboratory rats with nerve damage showed much less pain-related behavior after receiving injections of the HSV-based vector, which contained a gene called GAD, or glutamic acid decarboxylase. The treatment's pain-killing effect lasted up to six weeks, and even longer in rats that received additional injections.

The study is the first to demonstrate the successful use of gene transfer technology, using a herpes viral vector, to treat peripheral neuropathic pain in animals. Based on their success in related studies with research animals, the scientists hope to conduct the first clinical study in human patients soon.

"We use the vector to provide targeted gene delivery to the nervous system," says David J. Fink, M.D., the Robert W. Brear Professor of Neurology in the U-M Medical School and staff neurologist at the VA Ann Arbor Healthcare System, who co-directed the research study. "In this case, we're not trying to co
'"/>


1-Jun-2005


Page: 1 2 3 4

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
3. Scientists move closer to bio-engineered bladders
4. Scientists find stem cell switch
5. Scientists discover new way to study nanostructures
6. Scientists a step closer to understanding how anaesthetics work in the brain
7. Scientists to make news at Computational Biology Conference
8. Accident-prone? Scientists link brain function to knee injuries
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. Scientists find brown fat master switch
11. Scientists identify 2 distinct Parkinsons networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... ... January 03, 2019 , ... Over the ... into their drug discovery research workflows with biology ranging from single cell-type spheroids ... of in vitro studies, they create several challenges that need to be overcome ...
(Date:12/27/2018)... FRANCISCO (PRWEB) , ... December 27, 2018 , ... ... annual Microbiome Conference at JPM as part of the JP Morgan 37th Annual ... innovative scientists and physicians, and members of the investment community. , Since ...
(Date:12/20/2018)... ... December 20, 2018 , ... Human Factors and product ... a new usability/observation room. This addition will help meet the increased industry demand ... delivery devices/combination products are safe and easy to use when released to the ...
Breaking Biology News(10 mins):
(Date:1/10/2019)... Fla. (PRWEB) , ... January ... ... Geometrical Implant Co, (SAGICO), an innovative spinal implant company, announced today that ... in San Francisco, California. The annual J.P. Morgan Healthcare Conference is ...
(Date:1/7/2019)... SEONGNAM, South Korea (PRWEB) , ... January 07, ... ... has completed Phase 1 clinical trials of its Parkinson's Disease drug candidate, code-named ... disease-modifying treatment of Parkinson's Disease. The trial took place in South Korea. ...
(Date:1/4/2019)... ... January 03, 2019 , ... Calidi Biotherapeutics, Inc., ... today announced the founding of a scientific and medical advisory board (SMAB). The ... leaders in the Immuno-Oncology field. The founding members of Calidi Biotherapeutics SMAB include ...
(Date:12/18/2018)... ... December 17, 2018 , ... ABCT ... emerging biosciences ventures invited to participate in the annual program. Twelve ventures will ... plans and a professional network. All startups receive an entrepreneur coach, access to ...
Breaking Biology Technology:
Cached News: