HOME >> BIOLOGY >> NEWS
Screening approach leads to discovery of gene linked to breast cancer

BOSTON -- Using a novel three-part screening process, scientists at Dana-Farber Cancer Institute have identified a gene that is made inappropriately in about a third of all breast cancers. The discovery, reached in collaboration with researchers at Brigham and Women's Hospital (BWH) and the Broad Institute of Harvard and MIT, is reported in the June 15, 2007 issue of the journal Cell.

Unlike breast cancer-susceptibility genes such as BRCA1 and BRCA2, the newly identified gene, called IKBKE, is not inherited in a mutated form that increases the risk of developing breast cancer at an early age. Rather, the mutation arises during a woman's life, causing an overproduction of the IKBKE protein. That, in turn, spurs cell growth and proliferation. The mutation is found in 30-40 percent of all breast cancers, making it a prime target for future drugs for the disease.

The method used to home in on the gene -- a combination of three existing experimental approaches -- offers an elegant solution to one of the major hurdles of genome-age research: how to sift through the multitude of genes identified by advanced screening technology as potential cancer-causers to find those with the most profound role in the disease. As such, the new approach can be used to discover genes associated with many types of cancers, the study's authors state.

The genetic material within many human cancer cells is in such disarray that there can be numerous gene mutations," says the study's co-senior author, William Hahn, MD, PhD, of Dana-Farber, BWH, and the Broad Institute. Current technologies -- particularly 'microarray' sensors, which read the activity and changes in thousands of genes at a time enable us to locate dozens or even hundreds of gene abnormalities in cancer cells. The challenge is to winnow this group to find the genes most centrally involved in cancer initiation and maintenance.

"In the current study, we used several complementary approach
'"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
14-Jun-2007


Page: 1 2 3

Related biology news :

1. Screening for fragile skin
2. Screening for complex genetic interactions
3. Screening blood for West Nile virus
4. Screening chest x-ray detects early-stage lung cancers at high rates, study results show
5. NIH awards $11.9 M to The Burnham Institute to establish the San Diego Chemical Screening Center
6. Screening for genetic disorders: Need to avoid anxiety
7. Researchers use new approach to predict protein function
8. New approach to pulmonary hypertension shows promise
9. Personalized approach to ovarian stimulation achieves high ART pregnancy rates
10. New approaches to endometriosis treatment -- mouse experiments point the way
11. Reconstructing the biology of extinct species: A new approach

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... MA (PRWEB) , ... September 21, 2017 , ... ... proprietary clinical client portal. Each relaunch of the portal includes new features that ... and medical device companies seek to remain at the forefront of medical advancements, ...
(Date:9/21/2017)... SAN DIEGO, CALIF. (PRWEB) , ... September 21, 2017 , ... ... kitchen earlier this month. The organization, a worldwide society of professional women with ... a venue to hold its annual dinner. , Twelve members began with ...
(Date:9/20/2017)... ... 20, 2017 , ... Diversity focused business accelerator, The Refinery , announced ... to uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and ... entrepreneurial events going on that week – in Boston, it will be part of ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... From industry ... therapy succeeded after standard medicine failed. Many of these people had lost all hope. ... Regression Free Download (pdf) , “Neil takes readers on ...
Breaking Biology Technology:
Cached News: