HOME >> BIOLOGY >> NEWS
Screening for complex genetic interactions

In a report published online ahead of the January 15th print edition, Dr. David Amberg (SUNY Upstate Medical University) and colleagues have developed a large-scale reverse genetic screen to identify complex haploinsufficient interactions in S. cerevisiae. A complex haploinsufficiency (CHI) interaction is defined by heterozygous null/wildtype alleles in two different genes that combine to yield a more severe phenotypic defect. To illustrate the utility of this novel approach, the researchers culled through nearly 5000 strains of yeast to identify over 200 genes that interact with actin. This paper is one of the first examples of a large-scale CHI screen, and it is expected that this kind of systemic analysis will be particularly useful in uncovering complex genetic interactions in other organisms, including the study of human genetic disorders. Dr. Amberg states that "We knew that actin was an important gene but we were still surprised at the large number of CHI interactions we uncovered. This test case suggests that CHI interactions in complex organisms have major influences on phenotype."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
27-Dec-2006


Page: 1

Related biology news :

1. Screening for fragile skin
2. Screening approach leads to discovery of gene linked to breast cancer
3. Screening blood for West Nile virus
4. Screening chest x-ray detects early-stage lung cancers at high rates, study results show
5. NIH awards $11.9 M to The Burnham Institute to establish the San Diego Chemical Screening Center
6. Screening for genetic disorders: Need to avoid anxiety
7. Unravelling new complexity in the genome
8. How to structure a complex body plan
9. Bat flight generates complex aerodynamic tracks
10. Corals -- More complex than you?
11. Landmark study highlights complex genetic risk factors behind type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... August 16, 2018 , ... With increasing safety requirements, and ... research projects, are presenting multiple challenges. To be successful in such a competitive environment, ... different aspects of the multiple tasks needed to develop a new drug or to ...
(Date:8/14/2018)... ... 2018 , ... Career fairs provide an ideal setting for ... at once. However, healthcare professionals often have hectic schedules with little spare time ... providers who wish to explore opportunities and learn about multiple employers from the ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... and commercialization, is announcing the keynote for their NAVIGATE2018 conference. , ... as keynote speaker for NAVIGATE2018 , Cognition’s annual user conference. An experienced ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... ... its state-of-the-art Digital Vivarium™ and Vium Cloud approach to accelerate preclinical drug discovery ... Officer. Additionally, the company announced the appointment of Jeff Caron to the newly ...
(Date:7/25/2018)... ... 2018 , ... John McDonald, CEO of ClearObject , ... India Business Council (IIBC), an advocacy group to strengthen economic ties between Indiana ... McDonald joins an impressive roster of local and national business leaders from organizations ...
(Date:7/24/2018)... Texas (PRWEB) , ... July 24, 2018 , ... Boval ... to support blood bank reagent suppliers. In Boval’s early days most of the ... were added to produce BSA for diagnostic purposes after gel cards changed that market ...
(Date:7/22/2018)... ... 19, 2018 , ... Mitotech S.A, a Luxembourg based clinical ... 3 clinical program in Dry Eye Disease. Under the agreement Essex Bio-Investment will ... towards the first Phase 3 study starting as early as Fall 2018. ...
Breaking Biology Technology:
Cached News: