HOME >> BIOLOGY >> NEWS
Scripps Research study reveals new function of protein kinase pathway in tumor suppression

The study, led by Associate Professor Peiqing Sun and Professor Jiahuai Han of The Scripps Research Institute, is being published on January 26, 2007 in the journal Cell.

The research focused on signaling pathways that mediate an anti-tumor defense response called senescence, or cellular aging. The research, which was conducted in both human cell culture and rodent models with skin cancer or lymphoma, identified one essential element of this anti-tumor response, namely, p38-regulated/activated protein kinase (PRAK). Previous to this research, PRAK's physiological functions had been poorly understood.

"In uncovering this basic mechanism, we've advanced our knowledge in terms of how cancers develop," Sun said. "More importantly, we have identified a pathway in normal cells that, when activated, can inhibit tumor development. This lays the groundwork for new cancer therapy--for future drug development to artificially activate this pathway in cancer cells."

The human body has several built-in mechanisms that prevent cancer development. One is cell death, or apoptosis. Another is premature senescence, a recently identified tumor-restricting response that permanently stops cell proliferation.

"A normal cell stops dividing when it gets old," Sun explained. "This is referred to as senescence of a cell. A young cell will become senescent prematurely when it acquires a mutation that activates an oncogene. This is one of the ways our body tries to eliminate cells that might become cancerous."

In previous research that set the stage for this current project, Sun's lab worked to identify the signaling cascade that mediates ras-induced premature senescence (ras is an oncogene, a gene that, when activated by mutations, causes cancer by transducing unrestricted growth signals). Using human cells in culture, Sun's team showed that the p38 mitogen-activated protein (MAP) kinase is required for ras to induce senescence in cell cul
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
25-Jan-2007


Page: 1 2 3

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
6. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
7. Scripps research study reveals structural dynamics of single prion molecules
8. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... , ... The 19th Annual Bio-IT World Conference & ... and IT leaders goes VIRTUAL and announces its updated event features and full ... the leadership role of keeping our life science community connected by bringing you ...
(Date:8/7/2020)... Ky. (PRWEB) , ... August 06, 2020 , ... ... selected to participate in the prestigious National STEM Scholar Program, a unique professional ... network building, and project support for middle school science teachers nationwide. , Created ...
(Date:7/22/2020)... ... 21, 2020 , ... USDM Life Sciences , a ... a new solution to manage regulated workloads on Microsoft Azure. , Regulated biotechnology, ... complies with FDA and global regulations. USDM's new managed service for regulated workloads ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... , ... R3 Stem Cell International is now offering patients the opportunity to ... total, patients may choose which extremities they would like treated. , Several studies have ... 2016). At R3 International, umbilical cord tissue is obtained from a lab with a ...
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed ... Manager Regulatory Solutions, in a one hour live webinar on Thursday, August ... in China for drugs and medical devices. Specifically, for medical devices, the NMPA has ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
Breaking Biology Technology:
Cached News: