HOME >> BIOLOGY >> NEWS
Scripps research scientists identify infertility molecule

Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception.

In the latest issue of the journal Nature, the scientists detail how mice that lack LPA receptors, which normally appear on the surface of cells in a mouse's womb, have fertility problems. These mice are able to produce eggs normally, so that the eggs can be fertilized, but the resulting embryos, which are otherwise healthy, have problems implanting in the womb -- the last step in conception.

This is significant because women also have these LPA receptors expressed in their wombs. The discovery that the LPA receptors affect fertility in mice may open a new area of fertility research and treatment for humans.

"This is a receptor that wasn't on anyone's radar screen from a fertility standpoint," says Jerold Chun, M.D., Ph.D., who conducted the study with his research associate Xiaoqin Ye, M.D., Ph.D., and their colleagues at The University of Tokyo, Washington State University, and the Fred Hutchinson Cancer Research Center. "[These results] offer new insights on lipid signals and fertility."

If the receptors do turn out to be relevant to embryo implantation in humans, then the mechanisms involving these proteins might make good targets for therapeutic intervention, perhaps even leading to new treatments and successful pregnancies for some of the more than 6 million American women affected by infertility.

Fertility and the Demographics of the Western World

In the Western world, the last few decades have seen a dramatic shift in when women are choosing to have their first children. According to the U.S. Centers for Disease Control and Prevention, the average age of first-time mothers increased from about 21.4 in 1970 to nearly 25 in 2000.

Ma
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
4-May-2005


Page: 1 2 3 4 5

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
6. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
7. Scripps research study reveals structural dynamics of single prion molecules
8. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
9. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
10. Scripps Research study reveals new activation mechanism for pain sensing channel
11. NYU, Scripps finding offers new path for treatment of diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: