HOME >> BIOLOGY >> NEWS
Scripps research scientists identify new regulatory mechanism for critical protein signaling domain

m.

Sauer offers a helpful analogy for the newly uncovered mechanism: "IP4 acts very like a clever engineer. If you were trying to dock your ship at a space station but found that the docking stations weren't fully compatible, the station would send over an engineer called IP4 and he would reconfigure your dock to fit the space station."

Repercussions for T Cell Development

Signaling from T cell receptors triggers the generation of PIP3 and IP4, Sauer explained, leading to the recruitment of proteins to the cell membrane from the cytosol, the internal part of the cell. This receptor signal is part of the mechanisms by which T cells, key players of the immune system, protect us against attack by pathogens such as viruses. However, defective T cell development can lead to a number of immune diseases including allergies like asthma and autoimmune diseases like rheumatoid arthritis, while severely reduced T cell development or function can lead to immunodeficiency diseases such as AIDS.

Using a mouse mutant lacking ItpkB, the enzyme that produces IP4, Sauer and his colleagues showed that without the enzyme, T cells could not develop to maturity.

Because T cell development is regulated by receptor signaling, Sauer said, if the T cell doesn't signal properly, it is normally killed through programmed cell death or other mechanisms. In immature T cells-called double positive cells-if the signal is correct, the cells undergo positive selection in the thymus and are allowed to develop into mature CD4 or CD8 single positive (SP) T cells. Damaged or nonfunctional cells are eliminated.

"IP4 is generated after T cell receptor stimulation," he said. "We found that if IP4 cannot be made due to lack of ItpkB, important signaling molecules including the protein tyrosine kinase Itk can not be properly recruited to the cell membrane. Itk is a key activator of another enzyme, PLC g1, in T- cells. PLC g1 is important for signa
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
5-Apr-2007


Page: 1 2 3

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
6. Scripps research study reveals structural dynamics of single prion molecules
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... salient features of seizure risk signals, usually based on variations of amplitude, frequency ... the only acceptable diagnostic methodology due to the complexity and variability of the ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University of Vermont Health ... BioFactura’s $6M Series B Financing Round. , “With the commitment from the ... significant financial and business resources to bear as we advance our biopharmaceutical products ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... in a live webinar on Wednesday, June 19, 2019 at 1pm ... teams, medical review teams, data management teams and contract research organizations (CROs) can ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
(Date:5/15/2019)... ... 16, 2019 , ... Emulsifiers are the magic bullet when ... rely on these ingredients to create stable quality food that can withstand shelf-life ... triggers food formulators to seek out alternatives for starches, gums and chemical emulsifiers. ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three thousand ... Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), during ... results of some research carried out by the association, in partnership with scientists ...
Breaking Biology Technology:
Cached News: