HOME >> BIOLOGY >> NEWS
Scripps research scientists identify new regulatory mechanism for critical protein signaling domain

ling in many cells, because it generates the secondary messenger molecules IP3 and DAG (diacylglycerol). We found that ItpkB deficient double positive cells have reduced PLCg1 activity and cannot make normal amounts of DAG. Without the IP4 or DAG messengers, which are essential for positive selection of T cells, these ItpkB-deficient T cells cannot develop into mature, functional cells."

Positive selection of T cells is disrupted by this lack of IP4 and DAG in the mutant mice, the study noted. Quite remarkably, the authors could rescue several aspects of positive selection by treating ItpkB deficient cells with a DAG analog, PMA. DAG is well known for helping to mediate T cell receptor signaling by activating the Ras/Erk pathway, a key signal pathway whose misregulation is often involved in cancer. It is still too early to tell if IP4 plays a broader role in Ras regulation in other cells, Sauer said.

"This is something we stumbled into-the possibility of regulating the Ras pathway with IP4 at the level of DAG production through PLCg1," he said. "In the immature, double positive T cells, this circuitry is essential for positive selection. If you prevent IP4 production, you can never get positive selection-unless you provide a DAG analog like PMA-and that is a very provocative discovery."


'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
5-Apr-2007


Page: 1 2 3

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
6. Scripps research study reveals structural dynamics of single prion molecules
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/19/2019)... ... , ... VetStem Biopharma has long been a leader in veterinary ... of a two-year research collaboration with Calidi Biotherapeutics, VetStem has signed a worldwide license ... VetStem should be able to fast-track this cancer therapy for use in dogs due ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
(Date:7/10/2019)... FRANCISCO (PRWEB) , ... July 10, 2019 , ... ... Intelligent Virtual Agents for sales and service organizations, today announced its role ... experience and streamline the operational efficiency of its franchisees. A key part of ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... thinking on Data Integrity on July 08-09, 2019 in Boston, MA. This peer ... and medical device organizations. , The training will kick off with a compendial ...
(Date:5/21/2019)... (PRWEB) , ... May 21, 2019 , ... ... in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated to ... malting industry in Africa. The event, which is supported through a partnership with ...
(Date:5/14/2019)... ... 14, 2019 , ... Gateway Genomics , a leading developer of prenatal ... to 5,000 square feet. , “This past year has seen exponential growth for ... CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly to our customers ...
Breaking Biology Technology:
Cached News: