HOME >> BIOLOGY >> NEWS
Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

The Scripps Research team, led by neuroscientists Manuel Sanchez-Alavez and Tamas Bartfai, discovered that mice genetically altered to lack a molecule known as the EP3 receptor tend to be more active during their normal sleep cycle and to eat more. In the study, this led to weight increases of up to 30 percent relative to mice with the receptors.

The EP3 receptor is one of four types of receptors for prostaglandin E2 (PGE2), the most important inflammatory mediator that controls a variety of physiological functions including fever, fertility, and blood pressure. The most common anti-inflammatory and analgesic treatments like ibuprofen are aimed at reducing PGE2 signaling at all four prostaglandin receptors.

The absence of EP3 receptors has long been known to prevent fever response in mice, and it was this effect that the Scripps Research team was originally studying. Previous research on mice lacking the receptors had focused on fever inhibition until mice were about three months old. The team wanted to better understand the process by studying if fever inhibition continued later in life.

When the mice were four to five months old, the researchers made a startling discovery. The older mice still did not develop fever, but the researchers noticed that these mice were gaining weight.

"The experimental mice were clearly getting heavier than their wild type litter mates, the control mice," says Sanchez-Alavez. "We realized there was something interesting going on with these animals, so we started watching their behavior at night and during the day."

During continuous monitoring of temperature and motor activity, the researchers realized that the mice without the EP3 receptors were more active during the light hours-the nocturnal mice's "night"-and, more importantly, were eating during this time. The increased activity led to higher body temperatures, but this did not burn enough extra calories to balance the additi
'"/>

Contact: Marisela Chevez
mchevez@scripps.edu
858-784-2171
Scripps Research Institute
12-Feb-2007


Page: 1 2

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
6. Scripps research study reveals structural dynamics of single prion molecules
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Global demand for enzymes is ... 2020 to $7.2 billion.  This market includes enzymes ... products, biofuel production, animal feed, and other markets) ... biocatalysts). Food and beverages will remain the largest ... consumption of products containing enzymes in developing regions.  ...
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , ... announced today the Clinical Reach Virtual Patient Encounter CONSULT module which enables ... the physician and clinical trial team. , Using the CONSULT module, patients and physicians ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
Breaking Biology Technology:
Cached News: