HOME >> BIOLOGY >> NEWS
Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

The Scripps Research team, led by neuroscientists Manuel Sanchez-Alavez and Tamas Bartfai, discovered that mice genetically altered to lack a molecule known as the EP3 receptor tend to be more active during their normal sleep cycle and to eat more. In the study, this led to weight increases of up to 30 percent relative to mice with the receptors.

The EP3 receptor is one of four types of receptors for prostaglandin E2 (PGE2), the most important inflammatory mediator that controls a variety of physiological functions including fever, fertility, and blood pressure. The most common anti-inflammatory and analgesic treatments like ibuprofen are aimed at reducing PGE2 signaling at all four prostaglandin receptors.

The absence of EP3 receptors has long been known to prevent fever response in mice, and it was this effect that the Scripps Research team was originally studying. Previous research on mice lacking the receptors had focused on fever inhibition until mice were about three months old. The team wanted to better understand the process by studying if fever inhibition continued later in life.

When the mice were four to five months old, the researchers made a startling discovery. The older mice still did not develop fever, but the researchers noticed that these mice were gaining weight.

"The experimental mice were clearly getting heavier than their wild type litter mates, the control mice," says Sanchez-Alavez. "We realized there was something interesting going on with these animals, so we started watching their behavior at night and during the day."

During continuous monitoring of temperature and motor activity, the researchers realized that the mice without the EP3 receptors were more active during the light hours-the nocturnal mice's "night"-and, more importantly, were eating during this time. The increased activity led to higher body temperatures, but this did not burn enough extra calories to balance the additi
'"/>

Contact: Marisela Chevez
mchevez@scripps.edu
858-784-2171
Scripps Research Institute
12-Feb-2007


Page: 1 2

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research team sheds light on long-sought cold sensation gene
4. Scripps research study shows humans and plants share common regulatory pathway
5. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
6. Scripps research study reveals structural dynamics of single prion molecules
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... , ... Having proven that its Disruptor™ technology is more ... Green Cell Technologies® (GCT®), has turned its attention to the lucrative fruit ... methods, ushering in a new era of modern, cost effective and more natural ...
(Date:8/22/2017)... ... 22, 2017 , ... Cutting Edge Spine , a ... spinal implant technologies, announced today the appointment of Luke Maher as Director U.S. ... experience to directing Cutting Edge Spine’s national sales force, including 12+ years at ...
(Date:8/21/2017)... Kamuela/Waimea (PRWEB) , ... August 21, 2017 , ... ... based on the Big Island of Hawaii, is pleased to announce the first ... Trudeau, R(S) of MacArthur Sotheby’s International Realty is working together with listing agent ...
(Date:8/21/2017)... , ... August 21, 2017 , ... ... two speakers for this two-part educational webinar, in which attendees will learn about ... associated protein factor composition. Along with an overview of the development and validation ...
Breaking Biology Technology:
Cached News: