HOME >> BIOLOGY >> NEWS
Scripps research team sheds light on long-sought cold sensation gene

The discovery, reported in the May 3 issue of the journal Neuron, might one day lead to the development of drugs that induce cold sensation as an analgesic, or block it to prevent certain forms of chronic pain associated with cold sensation.

"This study represents the first demonstration that a single gene is responsible for most cool temperature sensation," says team leader Ardem Patapoutian, who has joint appointments with the Department of Cell Biology at Scripps Research and the Genomics Institute of the Novartis Research Foundation. "Many previous candidates have been postulated to play a role in our ability to sense cool temperatures, but none have withstood the test of genetics," he says.

TRPM8 was first discovered by Patapoutians group and proposed as a key gene controlling cold sensation. To test the hypothesis, the group observed the behavior of mice genetically altered to lack the gene in response to cold stimuli.

When placed in compartments with a temperature gradient, or in an enclosure where they could choose between two temperatures, mice without TRPM8 showed essentially no preference in the temperature range of 18 to 31C, suggesting their ability to sense this range was completely disabled without the gene. Normal mice, on the other hand, found cold temperature unpleasant, reliably avoiding cold temperatures in favor of warmer areas.

"Its pretty amazing that one gene could impact thermal sensation this much," says Ajay Dhaka, a Scripps Research postdoctoral fellow in the Patapoutian lab and lead author on the Neuron paper. "It really highlights the importance of the peripheral nervous system and how temperature affects our behavior," he says.

The altered mice also showed little response to the application of acetone to their hindpaw, which causes an unpleasant cold sensation, while the acetone caused normal mice to flick their paw and lick them.

TRPM8 codes for an ion channel found a
'"/>

Contact: Marisela Chevez
mchevez@scripps.edu
858-784-2171
Scripps Research Institute
2-May-2007


Page: 1 2

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
3. Scripps research study shows humans and plants share common regulatory pathway
4. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
5. Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
6. Scripps research study reveals structural dynamics of single prion molecules
7. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
8. Scripps Research study reveals new function of protein kinase pathway in tumor suppression
9. Scripps Research study reveals new activation mechanism for pain sensing channel
10. NYU, Scripps finding offers new path for treatment of diabetes
11. Reduced body temperature extends lifespan in study from the Scripps Research Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... ... geared toward clinical operations executives and focusing on all facets of clinical trial ... project management, portfolio management, resource management, patient engagement, and more. , “We ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... supports high-growth, high-impact life science and biotechnology companies, announced today that it ... foundations and disease-focused venture funds to discuss their investment philosophies, explain their ...
(Date:1/24/2019)... ... 2019 , ... rHEALTH LLC, an innovative digital health solutions ... United States Patent and Trademark Office (USPTO) for U.S. Patent Application No. 14/682,010, ... application covers the addition of a length scale to hydrogel microparticles. A ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... , ... January 30, 2019 , ... ... from pharma, academia and governmental agencies to discuss best practices for laboratory automation ... February 4-6. , At this year’s conference, Visikol will be at booth ...
(Date:1/24/2019)... ... January 22, 2019 , ... Controlled Contamination Services is ... in the US. Each of these valuable new team members will support its growing ... model moving forward as CCS scales its business. This addition will enable CCS to ...
(Date:1/21/2019)... FRANKLIN, Wis. (PRWEB) , ... January 21, 2019 ... ... company, announced their newest product line, SporActiv™, for the industrial and institutional cleaning ... a variety of residential and commercial cleaning needs. Applications include odor control, floor ...
(Date:1/20/2019)... ... January 17, 2019 , ... Today, Advanced Solutions, Inc., a ... specialized automation technology, titled Automate 3D. Automate 3D, produced by Advanced Solutions, allows ... to deliver to end-users, customers, and ERP systems. , Automate 3D ...
Breaking Biology Technology:
Cached News: