HOME >> BIOLOGY >> NEWS
Sea creature's toxin could lead to promising cancer treatment

DALLAS Feb. 5, 2007 -- A toxin derived from a reclusive sea creature resembling a translucent doughnut has inspired UT Southwestern Medical Center researchers to develop a related compound that shows promise as a cancer treatment.

In a study appearing online this week in the Proceedings of the National Academy of Sciences, the UT Southwestern scientists detail how the toxin blocks uninhibited reproduction of cultured human cancer cells while leaving healthy cells unaffected.

An accompanying study in PNAS shows that, in pre-clinical trials, a synthetic form of the toxin reduced human tumors implanted in mice without the harmful side effects seen using other cancer drugs. "Diazonamide is a special molecule it's teaching us more than we imagined," said Dr. Patrick Harran, professor of biochemistry and a senior author on both studies.

"This is a truly exciting result," said Dr. John Schwab, a program officer at the National Insti tutes of Health's National Institute of General Medical Sciences, which partly funded the work. "Not only has this UT Southwestern team identified a potent anti-cancer drug, but its unique mode of action avoids the kinds of side effects that make cancer chemotherapy so difficult. It's a great example of how NIH support for fundamental chemical research can benefit the American health-care consumer."

The animal, Diazona angulata, is a sea squirt a few inches wide that lives in colonies anchored to rocks. It was discovered offshore of the Philippines in 1990 as scientists were looking for species that might lead to useful drugs. From a few specimens, scientists extracted a tiny amount of a toxin, diazonamide A, which the animal probably uses to repel predators.

The toxin proved to kill cancer cells in culture, but so little of its natural form was available that a race soon began to synthesize it in the laboratory.

A chemical structure for diazonamide A was publis
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
5-Feb-2007


Page: 1 2 3

Related biology news :

1. New use for a cell toxin found to inhibit survival proteins in cancer cells
2. Children of smokers have more than 5 times higher levels of a nicotine toxin
3. Genome of Clostridium botulinum reveals the background to worlds deadliest toxin
4. Engineered protein effective against Staphylococcus aureus toxin
5. Anthrax paralyzes immune cells with lethal toxin, UF research shows
6. Gene that governs toxin production in deadly mold found
7. Bacterial response to oxidation studied as toxin barometer
8. Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
9. Algae toxin identification unravels fish-kill mystery
10. Red tide toxins leave beachgoers breathless
11. Study reveals molecular basis of botulism toxins deadly activity

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sea creature toxin could lead promising cancer treatment

(Date:3/23/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, announces its biometric payment technology, the Wocket® smart ... starting March 30 th . The ... New York markets. Gino ... our new ad campaign following the recent initial shipment of ...
(Date:3/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces its ... of the products featured in 2015 "I Want That" ... PM EST on the DIY Network.   ... Vegas , site of the 2015 International CES ...
(Date:3/18/2015)... Florida , March 18, 2015 ... as businesses, new revolutionary smart wallets and apps continue to ... Companies currently entrenched in the mobile payment industry in focus ... Group Holding Ltd. (NYSE: BABA ), Apple Inc. ... GOOG ) and Facebook Inc. (NASDAQ: FB ) ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
(Date:4/23/2015)... DIEGO , April 23, 2015  Neurocrine Biosciences, ... Company will report its first quarter 2015 results before ... Neurocrine will then host a live conference call and webcast ... update Thursday morning, April 30, 2015 at 8:00 a.m. ... can access the live conference call by dialing 866-952-1906 ...
(Date:4/23/2015)... Calif. , April 23, 2015  Veracyte, Inc. (NASDAQ: ... into a definitive agreement to sell approximately $40 million ... the agreement, the investors will purchase an aggregate of ... of $8.15 per share, the closing stock price on ... new and existing investors, including Broadfin Capital, Camber Capital, ...
(Date:4/23/2015)... 23, 2015  Metanome, Inc., an industry leader ... has changed its name to Diversigen, Inc.  The ... the single commercial source for the myriad of ... the diverse opportunities of the microbiome.  From the ... – including those that are difficult to handle, ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Delpor, ... today announced that the United States Patent and Trademark ... Company’s NANOPOR™ technology. US Pat. No. ... Delpor’s microfabricated drug delivery device for the ... proprietary NANOPOR™ technology for the sustained (zero-order) release of ...
Breaking Biology Technology:Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Veracyte, Inc. Announces $40 Million Private Placement 2Veracyte, Inc. Announces $40 Million Private Placement 3Veracyte, Inc. Announces $40 Million Private Placement 4Metanome Announces Corporate Name Change to Diversigen 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3
Cached News: