HOME >> BIOLOGY >> NEWS
Sea urchins' unexpectedly diverse 'innate' immune capability points to new research avenue

Inside that seemingly docile sea urchin there's a surprisingly active innate immune system, probably utilizing previously unrecognized immune mechanisms, that may also actively function in vertebrates, including humans, according to researchers at George Washington University, in Washington, D.C.

"Discovering this capability goes completely against the long-accepted paradigm that the innate immune system which had evolved over a long period of time was 'perfect' in terms of meeting lower animals' needs," L. Courtney Smith, associate professor of Biological Sciences, said. "It was a big surprise, that continues to astound us," she added.

Like many "lower" animals such as insects, earth worms and others without an adaptive immune system (one that can make antibodies), a sea urchin's innate system seems to produce a wide diversity of proteins that probably can attack germs and protect the sea urchin from infection, a new study from Smith's lab shows.

She and her colleagues studied the purple sea urchin's response to a standard bacterial insult (a fragment of the cell wall called lipopolysaccharide, or LPS) using a genomic screen. They discovered that the sea urchin produces a surprisingly large number of proteins against LPS, and that many of them are similar but also show an unexpected amount of variability.

Possible role of 'innate immunity' higher up the evolutionary ladder
"We are beginning to understand how an animal without an adaptive immune system can still protect itself," Smith said, adding: "We're beginning to appreciate that the sea urchin may use genes that are different from antibodies and possibly even different mechanisms from humans and yet is still able to produce an array of proteins with lots of diversity."

The paper, "Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate," appears in Physiolo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
5-Dec-2005


Page: 1 2 3 4

Related biology news :

1. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
2. Dog DNA study yields clues to diverse size of breeds
3. Grizzly bears feast on diverse diet
4. Earths most diverse marine life found off Indonesias Papua Province
5. Ocean microbe census discovers diverse world of rare bacteria
6. Smithsonian guide to the biodiverse marine environment of Panamas Bocas del Toro
7. Pathogens shape evolution of humans most diverse genes
8. Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
9. Bursts of waves drive immune system soldiers toward invaders
10. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
11. A stepwise retreat: How immune cells catch pathogens

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
Breaking Biology Technology:
Cached News: