HOME >> BIOLOGY >> NEWS
Sea urchins' unexpectedly diverse 'innate' immune capability points to new research avenue

Inside that seemingly docile sea urchin there's a surprisingly active innate immune system, probably utilizing previously unrecognized immune mechanisms, that may also actively function in vertebrates, including humans, according to researchers at George Washington University, in Washington, D.C.

"Discovering this capability goes completely against the long-accepted paradigm that the innate immune system which had evolved over a long period of time was 'perfect' in terms of meeting lower animals' needs," L. Courtney Smith, associate professor of Biological Sciences, said. "It was a big surprise, that continues to astound us," she added.

Like many "lower" animals such as insects, earth worms and others without an adaptive immune system (one that can make antibodies), a sea urchin's innate system seems to produce a wide diversity of proteins that probably can attack germs and protect the sea urchin from infection, a new study from Smith's lab shows.

She and her colleagues studied the purple sea urchin's response to a standard bacterial insult (a fragment of the cell wall called lipopolysaccharide, or LPS) using a genomic screen. They discovered that the sea urchin produces a surprisingly large number of proteins against LPS, and that many of them are similar but also show an unexpected amount of variability.

Possible role of 'innate immunity' higher up the evolutionary ladder
"We are beginning to understand how an animal without an adaptive immune system can still protect itself," Smith said, adding: "We're beginning to appreciate that the sea urchin may use genes that are different from antibodies and possibly even different mechanisms from humans and yet is still able to produce an array of proteins with lots of diversity."

The paper, "Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate," appears in Physiolo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
5-Dec-2005


Page: 1 2 3 4

Related biology news :

1. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
2. Dog DNA study yields clues to diverse size of breeds
3. Grizzly bears feast on diverse diet
4. Earths most diverse marine life found off Indonesias Papua Province
5. Ocean microbe census discovers diverse world of rare bacteria
6. Smithsonian guide to the biodiverse marine environment of Panamas Bocas del Toro
7. Pathogens shape evolution of humans most diverse genes
8. Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
9. Bursts of waves drive immune system soldiers toward invaders
10. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
11. A stepwise retreat: How immune cells catch pathogens

Post Your Comments:
(Date:3/5/2015)... 5, 2015 In Brazil , ... already using these solutions and 42 percent planning to invest ... approximately 25 percent of the companies will be investing in ... majority of companies in the region are currently opting for ... model will command significant attention in the coming years. This ...
(Date:3/2/2015)... March 2, 2015 Synaptics Inc. (NASDAQ: ... human interface solutions, today announced a new implementation ... to enable rapid and secure transactions and reliable ... gaming is a turnkey solution providing mouse and ... quickly integrate fingerprint ID solutions into their product ...
(Date:2/25/2015)... , Feb. 25, 2015  ABC Financial Services ... in the Health and Fitness Industry, today announced ... to MYiCLUBonline.  The latest upgrade includes advances to ... of cardless check-in via Identity One fingerprint biometrics. ... time through interactive displays at the International Health, ...
Breaking Biology News(10 mins):Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... "In America," the popular news television program that airs in ... legendary film actor James Earl Jones, has announced that it ... , Botany is commonly described as the scientific study ... bit more complicated than that. Scientists and other professionals study ... the smallest bacteria known to man to the largest trees ...
(Date:3/25/2015)... , March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ... that, as a result of recent discussions with certain ... shares of the Company, after dealing with certain matters ... special meeting of shareholders on March 26, 2015 (the ... the election of directors will take place when the ...
(Date:3/25/2015)... March 25, 2015 Accelovance, a therapeutically focused ... for "Best Contract Research Organization" at the upcoming Vaccine ... Congress. This is the eighth consecutive ... the award, winning for "Best Contract Research Organization" in ... distinction in 2013. "We,re excited to be ...
Breaking Biology Technology:BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
Cached News: