HOME >> BIOLOGY >> NEWS
Sea urchins' unexpectedly diverse 'innate' immune capability points to new research avenue

Inside that seemingly docile sea urchin there's a surprisingly active innate immune system, probably utilizing previously unrecognized immune mechanisms, that may also actively function in vertebrates, including humans, according to researchers at George Washington University, in Washington, D.C.

"Discovering this capability goes completely against the long-accepted paradigm that the innate immune system which had evolved over a long period of time was 'perfect' in terms of meeting lower animals' needs," L. Courtney Smith, associate professor of Biological Sciences, said. "It was a big surprise, that continues to astound us," she added.

Like many "lower" animals such as insects, earth worms and others without an adaptive immune system (one that can make antibodies), a sea urchin's innate system seems to produce a wide diversity of proteins that probably can attack germs and protect the sea urchin from infection, a new study from Smith's lab shows.

She and her colleagues studied the purple sea urchin's response to a standard bacterial insult (a fragment of the cell wall called lipopolysaccharide, or LPS) using a genomic screen. They discovered that the sea urchin produces a surprisingly large number of proteins against LPS, and that many of them are similar but also show an unexpected amount of variability.

Possible role of 'innate immunity' higher up the evolutionary ladder
"We are beginning to understand how an animal without an adaptive immune system can still protect itself," Smith said, adding: "We're beginning to appreciate that the sea urchin may use genes that are different from antibodies and possibly even different mechanisms from humans and yet is still able to produce an array of proteins with lots of diversity."

The paper, "Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate," appears in Physiolo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
5-Dec-2005


Page: 1 2 3 4

Related biology news :

1. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
2. Dog DNA study yields clues to diverse size of breeds
3. Grizzly bears feast on diverse diet
4. Earths most diverse marine life found off Indonesias Papua Province
5. Ocean microbe census discovers diverse world of rare bacteria
6. Smithsonian guide to the biodiverse marine environment of Panamas Bocas del Toro
7. Pathogens shape evolution of humans most diverse genes
8. Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
9. Bursts of waves drive immune system soldiers toward invaders
10. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
11. A stepwise retreat: How immune cells catch pathogens

Post Your Comments:
(Date:10/15/2014)... , Oct. 15, 2014 Sandata Technologies, ... home and community-based care, today announced it released ... Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™)  for ... a home health company founded in 1996 and ... . The study details the ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
(Date:10/14/2014)... in Cancer Research shows SIRT6—a protein known ... promote the development of skin cancers by turning on ... sun-damaged skin cells. , Previously considered protective, SIRT6 is ... that help regulate genomic stability and prevent some of ... DNA damage, which can lead to cancer. This study, ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
(Date:10/22/2014)... Research and Markets  has announced the addition of ... Geography - Global Analysis and Forecast (2014 - 2020)" ... electronics, also called as polymer electronics or plastic electronics, ... small conductive molecules and electrically conductive polymers. It is ... carbon based, made using synthetic strategies developed in the ...
(Date:10/20/2014)... Mapp Biopharmaceutical,s valiant effort to produce ... fight the Ebola outbreak will make the public ... of pharmaceuticals can be, according to Kalorama Information.  ... some may be taken aback by the three-month ... knowledge are well aware of the complex issues ...
(Date:10/20/2014)... 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... Q3 orders to $5.8 million and provides a good start to ... North America and one in the ... projects at record levels," said Peter Bruijns , President & ... end of Q3 than they have been for any complete year ...
Breaking Biology Technology:Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
Cached News: