HOME >> BIOLOGY >> NEWS
Sea urchins' unexpectedly diverse 'innate' immune capability points to new research avenue

Inside that seemingly docile sea urchin there's a surprisingly active innate immune system, probably utilizing previously unrecognized immune mechanisms, that may also actively function in vertebrates, including humans, according to researchers at George Washington University, in Washington, D.C.

"Discovering this capability goes completely against the long-accepted paradigm that the innate immune system which had evolved over a long period of time was 'perfect' in terms of meeting lower animals' needs," L. Courtney Smith, associate professor of Biological Sciences, said. "It was a big surprise, that continues to astound us," she added.

Like many "lower" animals such as insects, earth worms and others without an adaptive immune system (one that can make antibodies), a sea urchin's innate system seems to produce a wide diversity of proteins that probably can attack germs and protect the sea urchin from infection, a new study from Smith's lab shows.

She and her colleagues studied the purple sea urchin's response to a standard bacterial insult (a fragment of the cell wall called lipopolysaccharide, or LPS) using a genomic screen. They discovered that the sea urchin produces a surprisingly large number of proteins against LPS, and that many of them are similar but also show an unexpected amount of variability.

Possible role of 'innate immunity' higher up the evolutionary ladder
"We are beginning to understand how an animal without an adaptive immune system can still protect itself," Smith said, adding: "We're beginning to appreciate that the sea urchin may use genes that are different from antibodies and possibly even different mechanisms from humans and yet is still able to produce an array of proteins with lots of diversity."

The paper, "Macroarray analysis of coelomocyte gene expression in response to LPS in the sea urchin. Identification of unexpected immune diversity in an invertebrate," appears in Physiolo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
5-Dec-2005


Page: 1 2 3 4

Related biology news :

1. Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
2. Dog DNA study yields clues to diverse size of breeds
3. Grizzly bears feast on diverse diet
4. Earths most diverse marine life found off Indonesias Papua Province
5. Ocean microbe census discovers diverse world of rare bacteria
6. Smithsonian guide to the biodiverse marine environment of Panamas Bocas del Toro
7. Pathogens shape evolution of humans most diverse genes
8. Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
9. Bursts of waves drive immune system soldiers toward invaders
10. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
11. A stepwise retreat: How immune cells catch pathogens

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... Germany , December 15, 2016 ... announced an agreement with NuData Security, an award-winning ... partnership will enable clients to focus on good customer experience, ... protection regulation. ... In order to provide a one-stop fraud prevention suite, ...
(Date:12/15/2016)... LONDON , Dec. 15, 2016 /PRNewswire/ ... the driving experience, health wellness and wellbeing ... As one in three new passenger vehicles ... voice recognition, gesture recognition, heart beat monitoring, ... eyelid monitoring, facial monitoring, and pulse detection. ...
(Date:12/12/2016)... , Dec. 12, 2016  Researchers at ... possibilities for graphene by combining the material with ... highly sensitive pressure detector able to sense pulse, ... a small spider.  The research ... can be read here:  http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 19, 2017 , ... ... software solutions for pharmaceutical research and development (R&D), today announced the launch ... data analysis and interpretation for the rapidly evolving field of precision medicine. ...
(Date:1/19/2017)... ... January 18, 2017 , ... ... Health (NIH) to update its Data Sharing Policy. Specifically, the nation’s leading informatics ... applications subject to the existing policy. AMIA recommended that NIH earmark funding for ...
(Date:1/19/2017)... Jan. 18, 2017  Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ... immune therapies for operable and inoperable solid tumor cancers, ... Technical Officer of NW Bio, will present at the ... at the Hyatt Regency Hotel in Miami, ... the session entitled "New Therapeutic Approaches – Expanding the ...
(Date:1/18/2017)... , Jan. 18, 2017   Boston Biomedical , ... designed to target cancer stemness pathways, will feature data ... napabucasin, at the 2017 ASCO Gastrointestinal Cancers Symposium, held ... . Napabucasin is an orally-administered investigational ... STAT3. i Cancer stem cells (CSCs) possess the ...
Breaking Biology Technology:
Cached News: