HOME >> BIOLOGY >> NEWS
Self-assembled DNA buckyballs for drug delivery

ITHACA, N.Y. -- DNA isn't just for storing genetic codes any more. Since DNA can polymerize -- linking many molecules together into larger structures -- scientists have been using it as a nanoscale building material, constructing geometric shapes and even working mechanical devices.

Now Cornell University researchers have made DNA buckyballs -- tiny geodesic spheres that could be used for drug delivery and as containers for chemical reactions.

The term "buckyballs" has been used up to now for tiny spherical assemblies of carbon atoms known as Buckminsterfullerenes or just fullerenes. Under the right conditions, carbon atoms can link up into hexagons and pentagons, which in turn assemble into spherical shapes (technically truncated icosahedrons) resembling the geodesic domes designed by the architect-engineer Buckminster Fuller. Instead of carbon, the Cornell researchers are making buckyballs out of a specially prepared, branched DNA-polystyrene hybrid. The hybrid molecules spontaneously self-assemble into hollow balls about 400 nanometers (nm) in diameter. The DNA/polystyrene "rods" forming the structure are each about 15 nm long. (While still on the nanoscale, the DNA spheres are much larger than carbon buckyballs, which are typically around 7 nm in diameter.)

About 70 percent of the volume of the DNA buckyball is hollow, and the open spaces in the structure allow water to enter. Dan Luo, Cornell assistant professor of biological and environmental engineering in whose lab the DNA structures were made, suggests that drugs could be encapsulated in buckyballs to be carried into cells, where natural enzymes would break down the DNA, releasing the drug. They might also be used as cages to study chemical reactions on the nanoscale, he says.

The nanoscale, hollow buckyballs are also the first structures assembled from "dendrimerlike DNA." If three strands of artificial DNA are created such that portions of each strand are complementary to portions o
'"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University News Service
28-Aug-2005


Page: 1 2 3

Related biology news :

1. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
2. Researchers develop buckyballs to fight allergy
3. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
4. Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
5. New designer lipid-like peptide with lipid nanostructures for drug delivery systems
6. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
7. BEMA Fentanyl demonstrates substantial transmucosal delivery
8. Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
9. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
10. Nanoparticles for delivery of prostate cancer treatment
11. LED array signals successful binding of drug-delivery molecules to DNA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... ... August 30, 2018 , ... Vinita Madill, ... Novak, infrared materials engineer, LightPath Technologies. In the future, these names may be ... her 100th birthday. Today, they are among 26 scientists whose work and words ...
(Date:8/29/2018)... PASADENA, Calif. (PRWEB) , ... ... ... (“Fuzionaire Dx”), a radiopharmaceutical company unlocking the full power of positron emission ... in alkali metal catalysis, Fuzionaire Dx is helping clinicians and researchers study ...
(Date:8/26/2018)... ... August 25, 2018 , ... Maire Mayne, an evidence-based ... treated nutraceutical to reduce inflammation and autoimmune disorders and improve overall immune response. ... as inflammation. The following data was reported:,     Over 180% ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... 2018 , ... USDM Life Sciences , the leading risk management, technological ... that Manu Vohra will deliver a presentation at the BoxWorks 2018 conference ... for GxP in 30 Days” , When: Thursday, August 30, 1:00-1:50 PM PT, Where: ...
(Date:8/21/2018)... LEXINGTON, Mass. (PRWEB) , ... ... ... Corporation , a software company specializing in medical device compliance and commercialization, ... leveraging the Cockpit® platform. , Written and presented by Dr. Mario Kossmann, ...
(Date:8/17/2018)... ... August 17, 2018 , ... VANCOUVER, British ... Repositories (ISBER) is pleased to announce the release of the Russian translation of ... released in January 2018, is a practice-changing publication aimed at advancing the science ...
(Date:8/9/2018)... ... August 08, 2018 , ... ... expert services platform by combining its deep pharmaceutical compliance and technical expertise ... you meet periodic pharmaceutical GxP training requirements. , Bringing training to ...
Breaking Biology Technology:
Cached News: