The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Self-assembled DNA buckyballs for drug delivery

f another, the three strands will bind to each other over the complementary portions, creating a Y-shaped molecule. By joining several Y's in the same way, Luo's research group created molecules with several arms, a sort of tree shape (dendri- means tree in Greek). Then they attached polystyrene molecules to the dendrimerlike DNA forming a hybrid molecule called an amphiphile -- a molecule that both likes and hates water. DNA is hydrophillic -- attracted to water -- while polystyrene is hydrophobic -- water repels it.

The researchers expected the amphiphiles to assemble in water into some sort of solid structure arranged so that DNA would have a maximum interaction with water and polystyrene would avoid water as much as possible. Other researchers have used other amphiphiles to make spheres, rods and other solids. The hollow buckyballs were an intriguing and serendipitous surprise. A model suggests that one buckyball consists of about 19,000 amphiphiles, with their water-loving DNA mostly on the outside of the rods that form the structure. How these tens of thousands of molecules were able to self-organize to form such an intricate and complex structure is still an open question, the researchers say. They are seeking collaborators to solve the puzzle.

Luo and Ph.D. graduate students Soong Ho Um, Sang Yeon Kwon and Jong Bum Lee described DNA buckyballs in an invited talk titled "Self-assembly of nanobuckyballs from dendrimer-like-DNA-polystyrene amphiphiles" Sunday, Aug. 28, at the 2005 annual meeting of the American Chemical Society in Washington, D.C. They reminded the audience that although the geometry of solid truncated icosahedrons was first described by Archimedes on paper more than 2,000 years ago, the skeletal, hollow-faced version of buckyballs had not been envisioned until Leonardo da Vinci's illustrations in 1494.

Luo added that DNA buckyballs may turn out to have unusual electronic, photonic and mechanical properties, and that because D
'"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University News Service
28-Aug-2005


Page: 1 2 3

Related biology news :

1. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
2. Researchers develop buckyballs to fight allergy
3. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
4. Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model
5. New designer lipid-like peptide with lipid nanostructures for drug delivery systems
6. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
7. BEMA Fentanyl demonstrates substantial transmucosal delivery
8. Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
9. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
10. Nanoparticles for delivery of prostate cancer treatment
11. LED array signals successful binding of drug-delivery molecules to DNA

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Self assembled DNA buckyballs for drug delivery

(Date:11/22/2009)...herited gene deletion can increase the likelihood ...splantation, an international team of researchers ... Nature Genetics . When the gene, called UGT2B17,... the recipient,s, transplants have a significantly...aft-versus-host disease, in which immune cells fro...
(Date:11/22/2009)... the Brain Research Centre, a partnership of the U...and Vancouver Coastal Health Research Institute, h...by which brain cells die following a stroke, as we...results of the study were recently published onlin...ny brain cells continue to die even after blood fl...
(Date:11/20/2009)... report published in the November 2009 issue of th...scientists show how a family of genes (1-aminocycl... responsible for production of ethylene. This gas ...s information lays the foundation for future genet...istant, able to survive and thrive in difficult te...
Breaking Biology News(10 mins):Gene mismatch influences success of bone marrow transplants 2Gene mismatch influences success of bone marrow transplants 3Gene mismatch influences success of bone marrow transplants 4New understanding about mechanism for cell death after stroke leads to possible therapy 2It's a gas: New discovery may lead to heartier, high-yielding plants 2Cellzome Technology Used to Unravel Novel Regulatory Mechanism in Cancer Signaling Pathway 14104 1Cellzome Technology Used to Unravel Novel Regulatory Mechanism in Cancer Signaling Pathway 14104 2Scars of Bullying Linger 57417 1Forman Perry Watkins Krutz 26 Tardy Announces Take Nothing Verdict in Mississippi Asbestos Exposure Trial 57412 1Forman Perry Watkins Krutz 26 Tardy Announces Take Nothing Verdict in Mississippi Asbestos Exposure Trial 57412 2
(Date:11/23/2009)... Contec’s Sporicidin disinf...ve hospital-grade disinfectants against H1N1 and I...g, SC (PRWEB) November 24, 2009 -- Contec Inc, the...s announced that their Sporicidin disinfectants ...ll Influenza A viruses, including Pandemic 2009 H1...
(Date:11/23/2009)...MOUNTAINVIEW,Calif.,Nov.23/PRNewswire/--Frost&...carecompaniesfordemonstratingleadershipandinnovati...areInnovationAwardsBanquetheldinSanAntonio,Texas. ...0081117/FSLOGO ) ,, TheHealthcareInnovationAwar...ibutiontothedeliveryandmanagementofhealthcare.Such...
(Date:11/20/2009)..., , , , , , , ,... , AUDIO: , A team of scientists fro...ty of Arizona, Cold Spring Harbor Laboratory and I...NA of corn. The... , , Click here... , , , , , , , ...
(Date:11/20/2009)..., SEATTLE, Nov. 20 Den... that the U.S. Food and Drug Administration (FDA) ...s amended Biologics License Application (BLA) for ...se. The FDA has assigned a Prescription Drug User...e it will respond to Dendreon,s amended BLA. Dend...
Breaking Biology Technology:Sporicidin Brand Disinfectant Kills H1N1 in 3 Minutes 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 3Amaizing: Corn genome decoded 2Amaizing: Corn genome decoded 3Amaizing: Corn genome decoded 4Dendreon Receives FDA Acknowledgement of Complete Response 2Dendreon Receives FDA Acknowledgement of Complete Response 3
Other News:
... be ...genetically predisposed to developing sever...own ...the genes responsible. Now, a specific regi....chromosome by a consortium of researchers working...ychiatry and behavioral sciences at the ...Stanfor...
...andards and Technology (NIST) have created a stand...onmental scientists studying our everyday exposure..... Although a "standard house dust" may sound funn...t the potential for household grime to harbor harm...
...the diagnosis and treatment of two debilitating ch...rder (BD) and a syndrome called severe mood dysreg...s were measured during mildly frustrating situatio...tal Health (NIMH), of the National Institutes of H...
...ngly focuses on the environmental damage caused by...riations in the amount of greenhouse gas emissions... for.... Researchers funded by the Economic and So...University found that the climate change impact of...
Stanford-led study closes in on genes that may predispose some people to severe depression 2Stanford-led study closes in on genes that may predispose some people to severe depression 3Standardized house dust aids health researchers 2Extreme irritability -- is it childhood bipolar disorder? 2Extreme irritability -- is it childhood bipolar disorder? 3Traveling in the right direction -- lessening our impact on the environment 2
...ing a patented gene vector developed by the Univer...na-led research team is the first to...show that g...ls. This landmark...study, which paves the road f....March 16 issue of the Proceedings of the National...
...tions that hog operations in North Carolina have.b...nities across the state and.in areas with more non... North.Carolina at Chapel Hill study concludes... ...mental Health Sciences'.Environmental Justice Prog...
...ing glowing bacteria, scientists at the DuPont Co....ensive biosensors that rapidly.detect a key toxin ....environmental contaminants, including herbicides ...easier to pre-screen for potential.contaminants, i...
... .WHERE: The Wistar Institute, Joseph N. G...l 8, 1999, 7:30 a.m.. The Mitchell Ross Sym... Tumors of Childhood. 8:45 a.m. Sessi...ake Forest University School of Medicine. 9...
University Of Pittsburgh Involved In First Successful Example Of Gene Therapy For Pain Control 2University Of Pittsburgh Involved In First Successful Example Of Gene Therapy For Pain Control 3Research Reveals Environmental Injustice In N.C. Communities With Large Hog Farms 2Research Reveals Environmental Injustice In N.C. Communities With Large Hog Farms 3Glowing Bacteria: DuPont And UD Scientists Detect Poultry Toxin And Other Environmental Contaminants 2Wistar Institute To Host 3rd International Conference On Molecular And Clinical Genetics Of Childhood Renal Tumors And The Mitchell Ross Symposium 2