HOME >> BIOLOGY >> NEWS
Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway

Using a functional genomic screen, scientists have defined elements that impact the responsiveness of cancer cells to drugs commonly used as anticancer therapeutics. The research, published in the June issue of the journal Cancer Cell, published by Cell Press, identifies individual genes that are associated with resistance to chemotherapeutic drugs and sets the stage for future studies that may significantly enhance the ability to predict whether or not a particular tumor will respond to treatment.

Resistance to chemotherapeutic drugs is the primary cause of treatment failure in patients with metastatic cancer. Dr. Julian Downward from the Cancer Research UK London Research Institute and colleagues used RNA interference to directly examine the contribution of over 800 candidate proteins to the sensitivity or resistance of cancer cells to several drugs that are commonly used to treat cancer.

Using this technique, the researchers found that resistance to the chemotherapeutic agent paclitaxel, a member of the taxane family, as expected, involves genes that impair drug-induced mitotic arrest following knockdown. Silencing of these genes in many cases also induces polyploidy and multinucleation in the absence of drug treatment. The researchers conclude that specific disruption of the mitotic checkpoint promotes paclitaxel resistance and that chromosomal numerical heterogeneity may be a useful predictor of paclitaxel resistance in some cancers.

Ceramide metabolism was identified as a critical regulator of sensitivity to a wide range of chemotherapeutic drugs. Although ceramide has been associated with apoptosis for some time, the mechanisms have not been well understood. In this study, decreased expression of a ceramide transport protein, COL4A3BP, sensitized cancer cells to multiple cytotoxic agents. Further, expression of COL4A3BP was increased in drug-resistant tumor cells and in a small cohort of ovarian cancers following paclitaxel
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
11-Jun-2007


Page: 1 2

Related biology news :

1. Dog DNA study yields clues to diverse size of breeds
2. Grizzly bears feast on diverse diet
3. Earths most diverse marine life found off Indonesias Papua Province
4. Ocean microbe census discovers diverse world of rare bacteria
5. Smithsonian guide to the biodiverse marine environment of Panamas Bocas del Toro
6. Sea urchins unexpectedly diverse innate immune capability points to new research avenue
7. Pathogens shape evolution of humans most diverse genes
8. Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
9. A unique arrangement for egg cell division
10. Discovery in orange cauliflower may lead to more nutritious crops
11. When the villain becomes your friend: The strange tale of muscle lactate

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... , ... June 21, 2017 , ... ... office in North Carolina, and engages Timothy Reinhardt to manage the new site. ... leadership at Pfizer Inc, with his most recent role as the Director of ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... designating infertility as a disease, bringing new hope for prospective parents who are ... annual meeting to back the World Health Organization’s designation in hopes of changing ...
(Date:6/22/2017)... ... 2017 , ... The first human cell line HeLa, established in 1951, has ... cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination and ... and is associated with dramatic consequences for research. , In this educational webinar, ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext , ... directors has formed a Higher Education Entrepreneurship Advisory Committee to implement the recommendations ... and other high-ranking representatives from 35 higher education institutions across the state over ...
Breaking Biology Technology:
Cached News: