Serica scientists win AOSSM Award for ACL (knee) tissue regeneration in preclin...( of knees were clinically stable at all ...)

of knees were clinically stable at all points. Range of motion assessment indicated the knees maintained a normal range flexion and extension at all points. By 12 months, the initial SeriACL graft structure was not evident, indicating the devices ability to provide sufficient direction and space for substantial ligament ingrowth while being bioresorbed.

Current ACL repair options either an autograft or allograft each have well-documented, debilitating side effects, said Rebecca Horan, PhD, the studys lead author and Sericas Senior Director of Research and Development. Our goal with the SeriACL Graft is to provide a scaffold, or biomechanical support structure, implanted during a standard surgical procedure, which supports the development of functional ACL tissue, thereby avoiding the limitations and lengthy rehabilitation associated with existing options.

The SeriACL Graft or the surgical procedure did not induce early signs of acute inflammation, swelling or initial scar formation in the goat model, as indicated by rapidly declining scores for pain and knee size.

The primary focus of our work over the past ten years has been to solve the unmet clinical need in ACL repair, offering surgeons and patients a device that would create the correct environment within the knee to regenerate ACL tissue, while supporting the mechanical structure of the joint during the healing process. Our ultimate goal is for the SeriACL Graft to serve the patient over his or her lifetime, Altman added. Prior to our study, no one has shown successful 12 month ACL regeneration data in a large-animal model with an off-the-shelf product, due to the demanding mechanical and biological requirements of a functional ACL. We are delighted that the AOSSM has recognized this important work, which brought to bear the combined disciplines of mechanical, biomedical, chemical and textile engineering for the development of our SeriACL Graft.

This study, Cli
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Contact: Janna Guinen
jannag@comcast.net
781-834-7498
Spring Communications
13-Jul-2007

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